纤维素类手性固定相及高效液相色谱-旋光仪联用技术的研究  

The Research of Cellulose Derivatives as Chiral Stationary Phases and High Performance Liquid Chromatography with Polarimeter as On-line Detector

作　　者：张欣[1] 高连勋[1] 

机构地区：[1]中国科学院长春应用化学研究所,长春130022

出　　处：《分析化学》2001年第5期526-529,共4页Chinese Journal of Analytical Chemistry

摘　　要：合成了 3种纤维素衍生物并分别填充分析型色谱柱 ,研究了不同的涂敷条件对柱效的影响以及色谱柱的稳定性 ,对外消旋化合物进行了手性拆分。实现了高效液相色谱 旋光仪的联用 。Three cellulose derivatives were synthesized and used as chiral stationary phases based on silica gel. The effects of adsorbances on the column numbers and stabilities have been investigated. These stationary phases exhibited high chiral recognition for various racemates. At the same time, the on-line curves of polarimeter were obtained by high performance liquid chromatography with polarimeter as on-line detector.

关 键 词：手性固定相 高效液相色谱-旋光仪联用 外消旋化合物 柱效 纤维素 色谱柱 手性拆分 

分 类 号：O657.7[理学—分析化学]