萃取分光光度法测定盐酸洛美沙星  

Extraction-Spectrophotometric Determination of Lomefloxacin

作　　者：谭峰[1] 郎惠云[1] 李媛[1] 

机构地区：[1]西北大学化学系,西安710069

出　　处：《分析化学》2001年第5期561-564,共4页Chinese Journal of Analytical Chemistry

摘　　要：提出了测定盐酸洛美沙星 (LMX)的萃取分光光度法 ,该法基于在弱酸性条件下 ,盐酸洛美沙星与溴甲酚绿 (BMG)反应生成可被三氯甲烷萃取的离子对缔合物 ,其最大吸收波长为 415nm。药物浓度在 1～ 15mg/L(r=0 .9997)范围内符合比耳定律。表观摩尔吸收系数ε =2 .5× 10 4 L·mol-1·cm-1。最低检出限为 0 .0 14mg/L。回收率为 98.9%～ 10 1.6 %。Extraction-spectrophotometric method for determination of lomefloxacin is proposed. The ion pairs complex of lomefloxacin with bromocresol green (BMG) can be extracted into CHCl3 at pH 3.6 and has absorption maximum at 415 nm. The calibrationgraphs generated was linear over the range of 1 similar to 15 mg/L drug in solution (r = 0.9997). epsilon = 2.5 x 10(4) L.mol(-1).cm(-1). The detection limit is 0.014 mg/L. The recovery of method is 98.9% similar to 101.6%. The proposed method has been successfully applied to the determination of lomefloxacin in pharmaceutical formulations.

关 键 词：萃取分光光度法 盐酸洛美沙星 离子对缔合 抗菌素 药物分析 

分 类 号：O657.3[理学—分析化学]