解热镇痛药中氨基比林含量的示波极谱-铬酸钾滴定法测定  

Determination of Amidopyrine by OscillographicTitration with Potassium Chromate

作　　者：孟昭仁[1] 奚洪民[1] 张荣昌[1] 董国臣[1] 

机构地区：[1]北华大学师范学院化学系,吉林省吉林市132013

出　　处：《分析测试学报》2001年第4期77-79,共3页Journal of Instrumental Analysis

摘　　要：以K2CrO4 与氨基比林的氧化还原反应为基础 ,在1.5mol/LNH4Ac -NH4OH(pH8.2)极谱底液中 ,用K2CrO4 为标准溶液滴定氨基比林 ,以K2CrO4 在示波极谱图上切口的出现指示滴定终点 ,测定去痛片、安痛定片、克感敏片中氨基比林的含量。该法简便易行、灵敏、准确、终点直观、选择性强 。A method for the determination of amidopyrine in antipyretic analgesics was proposed based on the oxidation-reduction reaction between K2CrO4 and amidopyrine. In 1.5 mol/L NH4Ac-NH4OH(pH 8.2) base solution amidopyrine is titrated by K2CrO4 standard solution. The appearance of incision can be used to indicate the end point of the reaction. Common coexistent substances in tablets do not interfere in the determination. The method proved to be simple, selective, sensitive and accurate. It was applied to determine amidopyrine in tablets with satisfactory results.

关 键 词：示波极谱 铬酸钾 氨基比林 解热镇痛药 测定 滴定法 药物分析 

分 类 号：R971.1[医药卫生—药品] R917[医药卫生—药学]