毛细管区带电泳法测定复方磷酸可待因溶液有效成份  

Simultaneous Determination of Active Ingredients in Compound Codeine Phosphate Solution by Capillary Electrophoresis

作　　者：饶毅[1] 王义明[1] 罗国安[1] 

机构地区：[1]清华大学药物研究所,北京100084

出　　处：《分析科学学报》2001年第3期182-185,共4页Journal of Analytical Science

基　　金：国家自然科学基金 (No.2 963 5 0 2 2 0 )

摘　　要：应用毛细管电泳法测定了复方磷酸可待因溶液中磷酸可待因、盐酸麻黄碱、扑尔敏的含量。毛细管电泳的条件为 :37cm× 5 0 μm i.d(有效长度 30 cm)未涂层石英毛细管柱 ;分离电压 :1 5 k V;缓冲溶液 1 5 0 mmol/L NH4 Ac- H3PO4 ( p H2 .0 )。研究了方法的线性范围、精密度、回收率等 ,测定了三批样品。实验证明方法简便、快速。A new capillary electrophoresis method has been developed for the determination of codeine phosphate, ephedrine hydrochloride and chlorpheniramine maleate in compound codeine phosphate solution. The method employed a 150 mmol/L ammonium acetate phosphoric acid (pH 2.0) buffer solution, UV detection at 214 nm, electrophoresis voltage 15 kV and a capillary of 50 μm(i. d.)×37 cm. The established procedure has been applied to the determination of three batch samples. The result indicated that the proposed method was simple, rapid and reliable.

关 键 词：毛细管电泳法 复方磷酸可待因溶液 镇咳药 药物分析 磷酸可待因 盐酸麻黄碱 扑尔敏 

分 类 号：R974[医药卫生—药品] R917[医药卫生—药学]