流动注射光度法测定盐酸普鲁卡因  

Flow injection spectrophotometric determination of procaine hydrochloride

作　　者：樊静[1] 陈亚红[1] 叶存玲[1] 冯素玲[1] 

机构地区：[1]河南师范大学化学与环境科学学院河南省高等学校环境科学与工程重点学科开放实验室,新乡453002

出　　处：《分析试验室》2001年第3期34-36,共3页Chinese Journal of Analysis Laboratory

基　　金：河南省教委自然科学基金资助项目! (1 9991 50 0 3 0 )

摘　　要：在盐酸介质中 ,利用盐酸普鲁卡因 -亚硝酸钠 - α-萘胺的重氮化 -偶合反应 ,建立了流动注射光度法测定盐酸普鲁卡因的新方法。利用控制加权形心单纯形优化法选择最佳实验条件 ,测定的线性范围为 0～ 30μg/m L。A rapid and sensitive flow injection spectrophotometric method was proposed for determination of procaine hydrochloride. This method is based on the diazotisation of procaine hydrochloride with sodium nitrite in acidic medium and the coupling reaction with α naphthylamine. The optimal experimental conditions for the flow injection analysis were obtained by using the controlled and weighed centroid simplex method. The linear range of this method is 0～30 μg/mL. The method was successfully used to determine procaine hydrochloride in pharmaceuticals.

关 键 词：盐酸普鲁卡因 光度法 流动注射分析 药物分析 亚硝酸钠 Α-萘胺 重氮化-偶合反应 

分 类 号：R971.2[医药卫生—药品] R927.2[医药卫生—药学]