桂枝汤对大鼠血压双向调节作用及其有效部位探讨  

Experiment Studies on Dual-directional Regulation of Guizhitang for Rat Blood Pressure and Its Active Fractions of Guizhitang

作　　者：秦彩玲[1] 刘婷[1] 张毅[1] 孙玉茹[1] 孙有富[1] 姜廷良[1] 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2001年第4期20-23,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"九五"攀登项目!"中药现代化关键问题的基础研究"资助项目No :790 2 1 1 0 1 8

摘　　要：采用无损伤大鼠尾脉搏测压法 ,探讨了桂枝汤对大鼠血压的双向调节作用 ,并对其有效部位进行了筛选。结果表明 :桂枝汤能明显降低自发性高血压大鼠 (SHR)血压 ,能明显升高复方降压片致低血压大鼠血压 ,提示桂枝汤对大鼠血压具有明显双向调节作用 ;桂枝汤经化学分离提取所得A部分 (Fr.A)和E部分 (Fr.E)明显降低SHR血压 ,B部分 (Fr.B)明显升高复方降压片致低血压大鼠血压 ;提示Fr.A、Fr.E和Fr.B为桂枝汤大鼠血压双向调节作用的有效部位。Experimental studies Guizhi Tang on rat blood pressure of by non-invasive method demonstrated that Guizhi Tang had significant blood pressure decreasing effect for SHR. Guizhitang had obvious blood pressure increasing effect to Tabellae Reserpini Compsitae-induced low blood pressure rat. Experiment demonstrated that Guizhi Tang had significant dual-directional regulation on blood pressure for rat. Active fractions A(Fr.A) and E (Fr.E),isolated from Guizhi Tang had obvious blood pressure fall in SHR. Active fractions B(Fr.B),isolated from Guizhi Tang had obvious blood pressure rise for Tabellae Reserpini Compsitae-induced low blood pressure rat; The results show that Fr.A and Fr.E and Fr.B are active fractions of Guizhi Tang with dual-directional regulation on rat blood pressure.

关 键 词：桂枝汤 双向调节 血压 有效部位 自发性高血压大鼠 中药 药理 

分 类 号：R285.5[医药卫生—中药学]