猪苓汤对Thy-1大鼠肾炎模型相关细胞因子及基因表达作用研究  

Effect of Grifola Umbellata Decoction on Cytokines and Gene Expression Thy-1 Nephritis Rats

作　　者：全世建[1] 熊曼琪[1] 陈瑞春[1] 

机构地区：[1]广州中医药大学,广州510405

出　　处：《中国实验方剂学杂志》2001年第4期44-46,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：为探讨猪苓汤作用机制 ,选用Thy 1大鼠肾炎模型 ,以肝素作为对照进行研究。结果 ,病理造模组与正常对照相比 ,IL 1β、TNFα、IL 6、IL 6mRNA均高于正常 (P <0 0 1) ;猪苓汤组与肝素组的TNFα、IL 6、IL 1β、IL 6mPNA均低于造型组 (P <0 0 5 )。The model of glomerulonephritis was induced by monoclonal anti-Thy-1 antibodies.The level of IL-1β,TNF-α、IL-6,IL-6 mRNA expression was significantly was significantly incresed than the normal group. Those levels were significantly decresed when Grifola Umbellata decoction or heparin was administered.

关 键 词：猪苓汤 THY-1肾炎 细胞因子 中药 药理 

分 类 号：R285.5[医药卫生—中药学]