氯氮平治疗海洛因戒毒后心理渴求疗效观察  

The clinical study on clozapine treament for craving of heroin dependence

作　　者：李幸福 罗素兰 郁缪宇[2] 袁德基[2] 

机构地区：[1]四川成都市安康医院,610031 [2]华西医科大学附一院精神科

出　　处：《临床精神医学杂志》2001年第3期137-138,共2页Journal of Clinical Psychiatry

摘　　要：目的 :对戒毒后的海洛因依赖患者进行氯氮平治疗 ,观察其对心理渴求的效果。　方法 :43例自愿戒毒海洛因依赖患者 ,脱毒后由患者自愿选择氯氮平或纳曲酮治疗 ,使用自拟的心理渴求量表评定患者治疗前后渴求程度变化。　结果 :经氯氮平治疗 3月后 ,患者心理渴求评分较疗前有明显降低 ,有效率 6 5 .2 % ;而纳曲酮组治疗前后改变不明显 ,有效率为 2 0 .0 %。　结论 :氯氮平对海洛因依赖患者的心理渴求可能具有较好的疗效。Objective:To investigate the efficacy of clozapine in the treatment of psychological craving in heroin dependence after detoxification. Method:43 volunteers who had detoxified heroin dependence were treated with clozapine or naltrexone randomly,and evaluated with self-made craving scale. Results:The patients with clozapine had significant higher reducing rate of the craving scale than those with naltrexone after treatment for three months. Conclusion:It is suggested that clozapine may be effective in the treatment of craving for heroin in heroin dependence.

关 键 词：海洛因 氯氮平 纳曲酮 治疗 心理渴求 

分 类 号：R595.505[医药卫生—内科学]