中药骨必康对去卵巢大鼠骨矿含量、骨密度及其生物力学影响的实验研究  

THE INFLUENCE OF GUBIKANG ON BONE MINERAL CONTENT, BONE MINERAL DENSITY, BONE BIOMECHANICS IN OVARIECTOMIZED RATS

作　　者：宋永伟[1] 刘彦卿[1] 冯坤[2] 王健智[2] 张建福[1] 张灵菊[2] 陈宝龙[2] 刘月桂[2] 

机构地区：[1]河南中医学院,郑州450008 [2]河南省洛阳正骨医院正骨研究所

出　　处：《中医正骨》2001年第6期5-7,共3页The Journal of Traditional Chinese Orthopedics and Traumatology

摘　　要：为了观察补肾健脾中药对去卵巢大鼠骨矿含量、骨密度及其生物力学的影响 ,给其防治绝经后骨质疏松症提供实验依据。取 10月龄SD雌性大鼠 40只 ,随机分为模型组、正常对照组、阳性对照组、中药骨必康组 ,每组 10只 ,正常对照组行假手术。其余3组行完整双侧卵巢摘除术。术后第 3天开始灌胃给药 ,连续用药满 12周后处死 ,分离出L2 椎体及左侧股骨 ,测量其骨矿含量、骨密度 ,并进行生物力学测试。结果表明中药骨必康能明显增加去卵巢大鼠的骨矿含量与骨密度 (P <0 .0 5 ) ,有效维持椎体的生物力学性能 ,并对股骨的结构力学性能也有一定的维持作用。To observe the effect of kidney-tonifying and spleen-reinforcing traditional Chinese drug Gubikang on bone mineral content (BMC), bone mineral density(BMD), bone biomechanics in overiectomized rats, and to provide the experimental basis for the mechanisms of the prevention and treatment of postmenopausal osteoporosis by Gubikang. Forty female 10-month SD rats were divided randomly into 4 equal groups: model group, positive control group, Gubikang group, normal control group, and the former three groups were overiectomized, while the latter was made pseudo-operated models, then they all were treated by boiled water, nylestriol, Gubikang, boiled water. The rats were killed after the treatment of 12 weeks, and the 2nd lumbar vertebra and the left femur were taken out to determine BMC, BMD and biomechanical properties. Gubikang could increase the bone mineral content and the bone mineral density evidently, enhance the biomechanical properties of the vertebra, and improve the structural mechanics of the femur to some extent.

关 键 词：骨质疏松 中医药疗法 骨必康 骨矿含量 骨密度 生物力学 实验研究 

分 类 号：R285.5[医药卫生—中药学]