自体角质形成细胞在混合皮肤移植中诱导免疫抑制  

Immune suppression induced by auto-keratinoc-ytes in intermingled skin grafting

作　　者：周洪[1] 沈佰华[1] 李宁丽[1] 郑泽铣[1] 周光炎[1] 

机构地区：[1]上海第二医科大学上海市免疫研究所,上海200025

出　　处：《细胞与分子免疫学杂志》2001年第4期346-347,共2页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金资助;No.39870776

摘　　要：目的探索混合皮肤移植中，自体皮岛诱发移植免疫耐受的免疫机制。方法在体外建立混合表皮淋巴细胞(MELC)培养体系，以反映移植受者对皮肤移植物的免疫排斥反应。同时，将自体表皮细胞引入已建立的混合表皮淋巴细胞培养体系，以模仿混合皮肤移植中的自体皮岛效应,并分析发挥抑制效应的细胞来源。结果自体角质形成细胞可抑制淋巴细胞对同种异体抗原的增殖。结论自体皮岛中的角质形成细胞参与对同种异体抗原的提呈而诱导移植物耐受。：Aim To explore the mechanism of the immune tolerance induced by the auto-islets in the intermingled skin grafting. Methods The mixed epidermal cell and lymphocyte culture (MELC) was established, in which auto-keratinocytes were added to mimic the effect exerted by the auto-islets in vivo. Results Auto-keratinocytes could inhibit the lympho-proliferation induced by alloantigen. Conclusion The immune tolerance induced by auto-islets may be related to the function of auto-keratinocytes as antigen presenting cells.

关 键 词：混合皮肤移植 自体角质形成细胞 同种异体抗原提呈 免疫抑制 

分 类 号：R622.1[医药卫生—整形外科] R392.4[医药卫生—外科学]