肾移植受者环孢素A血药浓度变异系数的临床研究  

Clinical study of coefficient of variation of cyclosporine blood concentration in renal transplant recipients.

作　　者：王莉[1] 杨宇如[1] 卢一平[1] 沈宏[1] 唐科仕[1] 欧爱陵[1] 代波[1] 代波 

机构地区：[1]华西医科大学附属第一医院泌尿外科,成都610041

出　　处：《中华器官移植杂志》2001年第4期207-208,共2页Chinese Journal of Organ Transplantation

摘　　要：目的　研究环孢素A (CsA)血药浓度变异系数 (CV)的临床意义。方法　 185例尸肾移植受者 ,其中口服CsA微乳剂 (CsA ME)组 92例 (排斥反应 15例 ) ,口服CsA普通胶囊 (CsA GC)组93例 (排斥反应 2 1例 )。比较CsA ME组与CsA GC组CsA血药浓度变异系数的差异及排斥组与非排斥组CsA血药浓度变异系数的差异。结果　CsA ME组血药浓度变异系数小于CsA GC组 (P <0 .0 5 )。排斥反应组CsA血药浓度变异系数高于非排斥组的变异系数 (P <0 .0 5 )。结论　口服CsA ME血药浓度更稳定。排斥反应的发生与CsA血药浓度不稳定有关。CsA血药浓度变异系数是反映个体对CsA生物利用度变化大小的较可靠的指标 ,可以指导临床血药浓度的监测频度。Objective To evaluate the clinical implication of coefficient of variation (CV) of cyclosporine (CsA) blood concentration.Methods Of the 185 recipients of cadaveric renal transplantation, 92 were treated with the microemulsion of CsA (CsA-ME) (15 cases occurring rejection), 93 with the emulsion get caps (CsA-GC) (21 occurring rejection). The CV of CsA blood concentration in the CsA-ME group was compared with that in the CsA-GC group and the CV of CsA in the rejection group with that in the non-rejection group.Results The CV of CsA blood concentration was lower in the CsA-ME group than in the CsA-GC group (P< 0.05), and the CV of CsA blood concentration was higher in the rejection group than in the non-rejection group (P<0.05).Conclusions The blood concentration of CsA-ME is more steady than that of CsA-GC. The episode of rejection is associated with the unsteady concentration of CsA. CV is a valuable index reflecting the individual variability in cyclosporine pharmacokinetics in renal transplant recipients and can be used to determine the frequency of blood monitoring.

关 键 词：肾移植 环孢菌素 生物利用度 血药浓度 变异系数 

分 类 号：R699.2[医药卫生—泌尿科学] R979.5[医药卫生—外科学]