大黄胶囊预防脑梗塞并发应激性胃溃疡的实验研究  

Preventive Effects of Radix et Rhizoma Rhei Granule on the Occurrence ofComplicated Stress Ulcer of Stomach in Rats After Cerebral Infarction

作　　者：谭明义 陈根成 唐纯志[2] 

机构地区：[1]南海市中医院,广东南海528200 [2]广州中医药大学,广州510405

出　　处：《广州中医药大学学报》2001年第2期149-151,共3页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药管理局资助课题!(编号 :980 46 )

摘　　要：【目的】探讨大黄胶囊预防脑梗塞并发应激性胃溃疡的作用及机理。【方法】用大黄胶囊对以大脑中动脉闭塞法复制的脑梗塞模型大鼠进行预防性治疗。【结果】治疗后大鼠胃粘膜细胞凋亡指数降低 ,胃粘膜细胞增殖指数升高 ,胃粘膜和血浆内 5-羟色胺 (5-HT)含量下降 ,胃和血浆中去甲肾上腺素含量降低 ,胃内胆酸明显降低 ,胃液pH值增加 (与对照组比较P <0 .0 5或P <0 .0 1)。【结论】提示大黄胶囊可以保护实验性脑梗塞后胃粘膜免受损害和促进应激性胃溃疡的修复。Objective To explore the preventive effects of Radix et Rhizoma Rhei Granule on the occurrence of complicated stress ulcer of stomach (CSUS) in rats after cerebral infarction (CI) and its mechanism. Methods Rat models wi t h CI were established by the occlusion of middle cerebral artery. Preventive tre at ment of CSUS in rats after CI with Radix et Rhizoma Rhei Granule was carried out . Results As compared with the control group (Group A),apoptosis index of gastric mucosal cells was decreased and prolifer ation index increased, 5_HT level and noradrenaline (NE) content in gastric muco sa and plasma were declined, gastric and cholic acid reduced and pH value incre a sed in gastric juice of the treatment group(Group B) (P< 0.05 or 0.01 ). Conclusion Radix et Rhi zoma Rhei Gr anule can prevent gastric mucosa from damage in rats after CI and can promote th e repair of stress ulcer of stomach.

关 键 词：脑梗塞 并发症 胃溃疡 大黄胶囊 实验研究 中医药疗法 

分 类 号：R277.733.3[医药卫生—中医学] R259.731