去伤片对创伤瘀血模型大鼠血液流变学的影响及毒理研究  

Influences of Qushang Tablet on Blood Rheology in Rats with Traumatic Blood-Stasis Syndrome and Its Toxicological Study

作　　者：钟广玲[1] 陈渭良[1] 陈燕平[2] 杨梅香[2] 瞿长安[2] 

机构地区：[1]广东省佛山市中医院骨伤科研究所,广东佛山528000 [2]中国中医研究院骨伤科研究所,北京100081

出　　处：《广州中医药大学学报》2001年第2期167-170,共4页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】探讨由七叶一枝花等组成的去伤片活血化瘀的作用机理和临床应用的安全性。【方法】采用创伤瘀血模型大鼠观察去伤片对其血液流变学的影响 ,同时进行急性和慢性毒性研究。【结果】去伤片对创伤瘀血模型大鼠的血液流变学有明显影响 ,可改善血液的浓、粘、聚、凝状态 ;未见急性和慢性毒性反应。【结论】去伤片具有明显的活血化瘀作用 ,其临床应用是安全的。Objective To study the blood_flow_activating and blood_stasis_removi ng actions of Qushang Tablet (QT) and its safety. Methods Thirty rats were randomly allocated to Group A (normal control), Group B (models control) and G r oup C (treated with QT). Rat models with traumatic blood_stasis syndrome were in duc ed by the bruise of falling iron hammer. Effects of QT on blood rheology of rat model were studied. Acute and chronic toxic effect of QT was also studied. Res ults QT had obvious effect on blood rheology of rat model and could improve th e concentration, viscosity, aggregation and coagulability of blood. No acute and chronic toxic effect of QT was found. Conclusion QT exerts obvious blood_fl ow_activating and blood_stasis_removing actions and is safe to be applied in cli nic.

关 键 词：去伤片 药理学 血瘀 创伤 毒理 血液流变学 实验研究 

分 类 号：R285.5[医药卫生—中药学] R287.2[医药卫生—中医学]