血、尿内皮素水平与肾性高血压的研究  

Study on Plasma Levels of Endothelin-1 and Urinary Excretion Rate of Endethlin in Chronic Glomerulonephritis Patients with Renal Hypertension

作　　者：石蕾[1] 赵轶文[1] 张小平[1] 单若明[2] 

机构地区：[1]首都医科大学附属北京天坛医院肾内科 [2]首都医科大学检测中心

出　　处：《首都医科大学学报》2001年第2期135-137,共3页Journal of Capital Medical University

摘　　要：为探讨血、尿内皮素水平在肾性高血压及肾脏疾病发展中所起的作用 ,对正常人和慢性肾炎患者血浆内皮素 (PET 1 )、2 4h尿内皮素排泄量 (UET 1 )、内生肌酐清除率 (Ccr)和尿 β2 微球蛋白 ( β m)进行了检测。结果显示所有患者的PET 1和UET 1水平均升高 ,且PET 1或UET 1与平均动脉压 (MAP)和β m呈正相关 ,与Ccr呈负相关。提示 :血。To elucidate the effects on renal hypertension and progressive renal disease of endothelin 1 in patients of chronic glomerulonephritis, plasma endothelin 1 (PET 1), urinary excretion rate of endothelin 1 (UET 1), creatinine clearance (Ccr) and urinary excretion rate of β 2 microglobulin (β m) in 54 patients with chronic glomerulonphritis and those in 20 normal control were measured. The Results indicated the level of PET 1 and UET 1 in all patients was markedly elevated. There was a positive correlation between PET 1 or UET 1 and mean ertery pressure (MAP) and a negative relation between the former and β m. Correlation between PET 1 or UET 1 and Ccr were found. Endothelin plays an important role in developing renal hypertension and in porgressive renal disease and also UET 1 is a sensitive marker of renal tubular damage.

关 键 词：肾性高血压 内皮素 内生肌酐清除率 Β2-微球蛋白 

分 类 号：R544.14[医药卫生—心血管疾病]