糖类对先导化合物的化学修饰及其在药学中的应用  

Chemical modification of lead compounds by monasacchrides and their derivatives

作　　者：付新梅[1] 江涛[1] 王奎旗[1] 左代姝[1] 管华诗[1] 

机构地区：[1]青岛海洋大学海洋药物与食品研究所,青岛266003

出　　处：《中国海洋药物》2001年第3期54-56,共3页Chinese Journal of Marine Drugs

基　　金：山东省科委科技攻关计划 !(编号 :98116 480 2 );国家教委留学回国人员科研启动基金资助

摘　　要：概述了国内外有关糖类对先导化合物化学修饰的研究。从单糖、二糖和寡糖、多糖三个层面 ,分别对糖及其衍生物与先导化合物的键合方式、经过结构修饰的先导化合物的生物活性变化作了综述。结果表明 ,修饰过的先导化合物能有效地降低毒副作用 ,增强药效。所以 。As a summary of the research progress of chemical modification of lead compounds by saccharides and their derivatives, this article studies the linkage style of saccharides with lead compounds and bioactivity changes of the modified lead compounds. The result shows that the modified lead compounds can decrease the toxicity and side effect efficiently, and enhance the pharmacal effect. Therefore, it is a promising research project to modify lead compounds by saccharides.

关 键 词：糖类化合物 先导化合物 化学修饰 

分 类 号：R977.6[医药卫生—药品] R962[医药卫生—药学]