盐酸左旋氧氟沙星注射液的研制  

The research and preparation of levofloxacine hydrochloride injection

作　　者：左六一[1] 叶荻庆[2] 赵语[1] 徐富培[1] 

机构地区：[1]重庆医科大学临床学院药剂科,重庆400016 [2]重庆医科大学临床学院检验科,重庆400016

出　　处：《重庆医科大学学报》2001年第2期177-178,共2页Journal of Chongqing Medical University

摘　　要：目的：对盐酸左旋氧氟沙星注射液的处方和制备工艺进行了研究。方法：采用紫外分光光度法测定制剂中盐酸左旋氧氟沙星含量，用HPLC法测定有关物质，并进行了定性及卫生学等项检查。结果：本研究研制的盐酸左旋氧氟沙星注射液，制备工艺简单，含量测定快迅、准确。结论：该制备工艺可用于常规制备盐酸左旋氧氟沙星注射液。Objective: The prescription and the procedure of preparing the levofloxacine hydrochloride injection was studied. Methods: The levofloxacine hydrochloride content of the preparation was determined by ultraviolet-spectrophotometer. The related-material was measured by HPLC. The qualitative analysis and hygienical examination were done too. Results: All this show the procedure of preparation is simple,and the quantitative determination is quick and accurate. Conclusion: The results indicated that the procedure can be used to prepare the levofloxacing hydrochloride injecton as a rule.

关 键 词：盐酸左旋氧氟沙星 注射液 制备 含量 测定 

分 类 号：R978.19[医药卫生—药品] R944.11[医药卫生—药学]