西沙必利对健康志愿者胆囊排空的作用  

Effects of cisapride on gallbladder emptying in the healthy volunteers

作　　者：张霞[1] 唐承薇[1] 钟晓明[2,3,4] 

机构地区：[1]重庆医科大学临床学院消化内科,重庆400016 [2]重庆医科大学临床学院B超室 [3]胆囊容积 [4]胆囊排空

出　　处：《重庆医科大学学报》2001年第2期179-180,共2页Journal of Chongqing Medical University

摘　　要：目的：了解西沙必利对健康人类胆囊张力及餐后胆囊排空的影响。方法：应用B型超声仪测定了15 例健康志愿者服用西沙必利前后的空腹和餐后的胆囊容积，并计算其对胆囊排空率的影响。结果：15例健康志愿者口服西沙必利前、后空腹胆囊的容积无明显改变 (Ｐ＞0.05)。服用西沙必利后的餐后30min胆囊容积较服西沙必利前明显缩小(Ｐ＜0.05)。服西沙必利后胆囊排空率显著增加 (Ｐ＜0.001)。 结论：西沙必利对空腹胆囊容积无明显影响，但可显著促进餐后胆囊的收缩及排空。Objective: To study effects of cisapride on the human gallbladder volume and emptying. Methods: Fasting and postprandial gallbladder volumes were measured with ultrasonography in 15 healthy volunteers before and after taking cisapride orally. Gallbladder volumes were normalized to gallbladder ejection frequency (GBEF). Results: The fasting gallbladder volume in 15 healthy subjects did not change before or after cisapride administration (Ｐ>0.05). Postprandial gallbladder volume 30min after taking became smaller than that before taking cisapride (Ｐ<0.05). GBEF was significantly enhanced that after cisapride administration(Ｐ<0.001). Conclusion: Cisapride had no effect on the fasting gallbladder volumes but significantly promoted postprandial gallbladder contraction and emptying.

关 键 词：西沙必利 胆囊容积 胆囊排空 

分 类 号：R975[医药卫生—药品] R575.6[医药卫生—药学]