T_2毒素对大鼠心肌能量代谢的影响  

The effect of T_2 on the energy metabolism of rat myocardium and the protection of selenium and vitamin E

作　　者：殷秀云[1] 刘美娜[2] 张卫星[1] 迟月明[1] 万汇涓[1] 周令望[1] 王敏[1] 刘红[1] 曾宪惠[1] 曾绍娟[1] 

机构地区：[1]哈尔滨医科大学克山病研究所,黑龙江哈尔滨150086 [2]哈尔滨医科大学公共卫生学院,黑龙江哈尔滨150001

出　　处：《中国地方病学杂志》2001年第4期262-264,共3页Chinese Jouranl of Endemiology

基　　金：黑龙江卫生厅科教处资助 ( 98113)

摘　　要：目的　探讨 T2 毒素致大鼠心肌损伤的机制。方法　通过慢性毒理学实验 ,运用电镜酶学、生理酶学及高效液相色谱技术 ,观察 T2 毒素对大鼠心肌能量代谢的影响。结果　 T2 毒素可使大鼠心肌组织中 ATP含量、线粒体呼吸链呼吸酶、细胞色素氧化酶活力以及 ATP酶活力下降。结论　 T2 毒素可能通过损害大鼠心肌能量代谢而导致心肌不可逆损伤 ,加硒或加维生素Objective To study the injury mechanism of T 2 toxin to the myocardium of rats.Methods The activities Cyt-c and ATPase were measured by electron microscopic,enzymology and biomedical enzymology.The contents of ATP,ADP,AMP in the myocardium of rats were tested by HPLC.Results T 2 toxin could reduce the content of ATP in myocardium and decrease the activity of Cyt-c and ATPase.Conclusions T 2 toxin can induce irreversible myocardium damage through impairing myocardial energy metabolism.Supplementation of selenium or vitamin E may partially antagonize this damaging effect.

关 键 词：T2毒素 心肌组织 能量代谢 硒 维生素E 大鼠 

分 类 号：R542.2[医药卫生—心血管疾病]