大鼠甲状腺对碘酸钠及碘化钠摄取率的对比研究  

Comparison of Thyriod Uptake Iodine from Na^( 131)IO_3 and Na^(131)I in Rats

作　　者：朱学良[1] 邸红军[1] 陈贯一[2] 项建梅[2] 戴玉洁[1] 王毅[2] 阎玉芹[2] 赵文德[2] 陈祖培[2] 

机构地区：[1]天津医科大学病理生理教研室,天津300070 [2]天津医科大学内分泌研究所,天津300070

出　　处：《中国地方病学杂志》2001年第4期275-276,共2页Chinese Jouranl of Endemiology

基　　金：天津市自然科学基金项目 ( 9736 0 80 11)

摘　　要：目的　评价碘酸钾取代碘化钾制作碘盐预防碘缺乏病的效果。方法　将正常 Wistar大鼠和长期低碘繁殖的 Wistar大鼠各分为实验组 (L I,L - L I) ,低碘饲料 ,饮无离子水 ;对照组 (N,L - N ) ,低碘饲料 ,饮 KI水。饲养 3个月后注射 Na1 3 1 IO3 和 Na1 3 1 I观察甲状腺对碘的摄取率。另外 ,给低碘鼠补 KIO3 和 KI 3个月后测尿碘的排出量。结果　经腹腔注射 Na1 3 1 IO3 和 Na1 3 1 I6 h后测得的甲状腺吸碘率 ,在 4组中均显示 :注射 Na1 3 1 I组甲状腺摄碘率高于注射 Na1 3 1 IO3 ,但差异无显著意义。尿碘排出量 ,补 KIO3 组高于 KI组 ,差异也无显著意义。甲状腺吸碘率在实验组 (L I、L - L I)为对照组 (N、L - N )的 8～ 10倍 ;而尿碘排出量实验组为对照组的 1/ 15～ 1/ 5 0。结论　碘酸盐 (KIO3 )和碘化物 (KI)中的碘均能被甲状腺摄取。因此 。Objective Evaluated effect of treatment producting salt iodization with KIO 3 instant of KI.Methods Injected Na 131IO 3 into abdominal cavity of rats with in semi-number and another half rats are infected Na 131I in rats of 4 groups.Later 6 hours records value of uretic iodine and thyroid uptake iodine by γ-radial immunity counter.Results In 4 groups,ability of thyroid uptake iodine from Na 131I is more than from NaIO 3,but no difference in statistical.Excreted amount of iodine in urine is higher in groups of uptake KIO 3.Uptake iodine rate in LI group is 56.49% and 5.12% in control group.Conclusions Thyroid can uptake iodine not only from KI,but also from KIO 3.Therefore,eliminate iodine deficiency preparation of salt iodization,using potassium iodinate and potassium iodide have the same effects for utilized iodine of body.

关 键 词：碘缺乏病 甲状腺吸碘率 尿碘 大鼠 预防 

分 类 号：R599.9[医药卫生—内科学]