摄碘量增加对缺碘病区格雷夫斯病的影响  

The clinical manifestation analysis of Graves' Disease patients for containing iodine food or drugs during treatment with antithyroid drugs

作　　者：孙增君[1] 马玉琴[1] 王金彪[1] 许耀玲[1] 

机构地区：[1]山东省地方病防治研究所同位素病房,山东济南250014

出　　处：《中国地方病学杂志》2001年第4期308-310,共3页Chinese Jouranl of Endemiology

基　　金：山东省卫生厅资助课题 ( 1996 CA2 DKA1)

摘　　要：目的　对来自缺碘病区、经治疗后症状、体征消失而使用维持量抗甲药物的格雷夫斯病 (Graves'Disease,GD)患者 ,摄碘量增加后的临床特点进行分析。方法　对上述 GD患者的临床症状、体征进行统计 ,对其甲状腺激素水平、甲状腺自身抗体水平、甲状腺吸碘率等进行测定 ,并与无摄碘量增加的、使用维持量的现症 GD患者进行了比较。结果　 32例摄碘量增加的 GD患者的临床症状、体征及实验室检查结果均雷同于 34例现症GD患者。结论　 GD患者在治疗过程中可因摄碘量增加导致甲亢复发 ,造成症状加重且不易被控制 ,应作为现症GD患者重新制订治疗方案。但其临床症状、体征又有别于碘致性甲亢。治疗上可选择抗甲药物、放射性碘或手术治疗。发病机制可能与碘对Objective To study the clinical manifestation of the Graves' Disease (GD) patients with hyperthyroidism after increasing food iodine and treated with antithyroid drugs.Methods The clinical symptoms?signs of 32 patients with hyperthyroidism caused by eating iodine food or drugs were analysed (GD 1 group) ?the level of FT 3?FT 4?TSH?TGAb?TMAb?RAIU(%) were measured and compared with GD (GD 2 group).Results The clinical symptoms?signs?assist examination results of 32 patients of GD 1 group were similar with GD 2 group.Conclusions The Graves' Disease patients fall ill hyperthyroidism in the course of treatment with anti-thyroid drugs was caused by containing iodine food or drugs. Perhaps the attack of mechanism of hyperthyroidism was related with the effect of immune system function by iodine.

关 键 词：碘致性甲亢 格雷夫斯病 自身免疫性甲状腺疾病 碘缺乏病 摄碘量 

分 类 号：R599.9[医药卫生—内科学]