冠心病患者血小板PKC、PKCI及红细胞PKC活性变化  

Protein kinase C and its inhibitor activity in platelets and protein kinase C activity in erythrocytes from patients with coronary heart disease

作　　者：葛华[1] 许讳东[1] 周霞[1] 张红[1] 李楠[1] 

机构地区：[1]沈阳医学院附属中心医院循环内科,沈阳110024

出　　处：《中国心血管杂志》2001年第3期125-127,133,共4页Chinese Journal of Cardiovascular Medicine

摘　　要：目的 研究蛋白激酶C(PKC)在冠心病的发生发展中的作用。方法 测定87例心绞痛(AP)患者、91例急性心肌梗死(AMl)患者、90例健康对照(HC)者的血小板胞膜、胞浆PKC、胞浆蛋白激酶C抑制剂(PKCl)活性和红细胞胞膜、胞浆PKC活性。结果 AP组和AMI组血小板胞膜中PKC活性明显高于HC组,而胞浆中PKC活性明显低于HC组;AP组和AMI组血小板胞浆中PKCI活性明显低于HC组;AP组和AMI组红细胞胞膜中PKC活性明显高于HC组,而胞浆中PKC活性低于HC组。结论 PKC可能参与冠心病的发病。Objective To study the relation between protein kinase C(PKC) and coronary heart disease. Methods To measure the activity of PKC and its inhibitor (PKCI) in platelets,the activity of PKC in erythrocytes from patients with angina pectoris (AP), patients with acute myocardial infarction (AMI),and healthy control subjects (HC),respectively. Results The activity of PKC in membrane of platelets from AP and AMI were higher than those of HC, the activity of PKC in cytosol of platelets from AP and AMI were lower than those of HC; The activity of PKCI in cytosol of platelets from AP and AMI were lower than those of HC;The activity of PKC in membrame of erythrocytes from AP and AMI were higher than those of HC.the activity of PKC in cytosol of erythrocytes from AP and AMI were lower than those of HC. Conclusion PKC is likely to be associated with the pathogenesis of coronary heart disease.

关 键 词：冠心病 蛋白激酶C 蛋白激酶C抑制剂 血小板 红细胞 PKC 

分 类 号：R541.4[医药卫生—心血管疾病]