绞股蓝总苷对老化小鼠脑中MAO和Na/K-ATP酶活性的影响  

Effects of gypenosides on monoamine oxidase and Na/K-ATPase activities in brain tissues of aging mice

作　　者：龚国清[1] 钱之玉[1] 周曙[1] 

机构地区：[1]中国药科大学药理教研室,江苏南京210009

出　　处：《中草药》2001年第5期426-427,共2页Chinese Traditional and Herbal Drugs

摘　　要：目的　研究绞股蓝总苷对老化小鼠脑中 MAO和 Na/ K- ATP酶活性的影响。方法　采用连续眼球后注射D-半乳糖 1个月 ,造成小鼠老化模型 ,观察绞股蓝总苷对老化鼠脑中单胺氧化酶 (MAO)和 Na/ K- ATP酶的活性影响。结果　老化小鼠可造成脑中 MAO活力的升高和 Na/ K - ATP活力的降低 ,而绞股蓝总苷在造模型同时 ig给药 ,每日剂量 75和 15 0 m g/ kg下 ,能逆转小鼠因老化而产生的上述二种酶活性的改变。结论　绞股蓝总苷能对抗老化小鼠因衰老引起的 MAO和 Na/ K- ATP酶的活性改变 ,从生化酶学角度 。Object To study the effects of gypenosides on MAO and Na/K ATPase activities in brain tissues of aging mice Methods Models of aging mice were prepared by continuous post orbitol injection of 120 mg/kg D galactose for a month, then the effects of gypenosides on MAO and Na/K ATPase activities in brain tissues were investigated Results It was observed that MAO activity was increased and Na/K ATPase activity was decreased in brain tissues of aging mice models significantly; and these effects were reversible respectively by gypenosides ig of 75 and 150 mg/kg Conclusion The result that gypenosides could invert the changes of MAO and Na/K ATPase activities in brain tissues of aging mice, may provide a further explaination of the anti aging mechanism of gypenosides in molecule enzymology

关 键 词：绞股蓝总苷 老化小鼠 单胺氧化酶 Na/K-ATP酶 

分 类 号：R285.5[医药卫生—中药学]