富马酸酮替芬雾化液的研制  

Preparation of Ketotifen Fumarate Spraying Solution

作　　者：张伟烈[1] 李亦陵 李苏明[1] 吴建国[1] 

机构地区：[1]常州市气管炎研究所,江苏常州213003

出　　处：《中国医药工业杂志》2001年第5期205-207,共3页Chinese Journal of Pharmaceuticals

摘　　要：采用正交试验筛选出了富马酸酮替芬雾化液的处方 ,并用初均速法对该溶液的稳定性进行了初步研究。结果表明 ,其分解反应的活化能 E为 117.3k J· mol- 1 ,有效期 τ2 5°C0 .9为 3.Orthogonal method was used to formulate the ketotifen fumarate spraying solution. The stability of the spraying solution was studied primarily by using the initial average rate method. The results showed the shelf life at 25°C was 3.2 years. The activation energy of the decomposition reaction was 117.3 kJ·mol -1 .

关 键 词：富马酸酮替芬 雾化液 稳定性 抗变态反应 正交试验 

分 类 号：R976[医药卫生—药品] R927.11[医药卫生—药学]