左旋四氢帕马汀在大鼠急性全脑缺血再灌注时对能量代谢内皮素-1及一氧化氮的影响  

Effects of L-Tetrahydropalmatine on energy metabolism eodothelin-1 and NO during acute cerebral ischemia-reperfusion of rats

作　　者：蒋崇慧[1] 杨光田[2] 汤彦[2] 邓普珍[2] 

机构地区：[1]广东省中山市人民医院急救中心,528400 [2]同济医科大学附属同济医院急诊科,武汉430030

出　　处：《中国急救医学》2001年第6期317-318,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的　了解左旋四氢帕马汀 (L -THP)在大鼠急性全脑缺血再灌注损伤中对一氧化氮 (NO)、内皮素 1(ET 1)、三磷酸腺苷 (ATP)及乳酸的影响 ,探讨L THP对脑缺血再灌注损伤的保护作用。方法　采用Pulsinelli方法建立大鼠急性全脑缺血再灌注损伤模型。观察L THP在再灌注期间对NO、ET 1及能量代谢的影响。结果　L THP可抑制再灌注早期NO、ET - 1及乳酸的过量产生 ,提高ATP含量。结论　L -THP可以通过对NO、ET 1及能量代谢的影响对大脑起保护作用。Objective To find the influence of L_Tetrahydropalmatine(L-THP)on NO,ET_1,ATP and Lactate in the brain tissues after the global ischemia_reperfusion of rats and the protective effects of L_THP were also observed.Methods The four_vessel occlusion models was made as discribedd by pulsinelli.Observing the influencce of L_THP on NO,ET_1 and energy metabolism during the reperfusion period.Results L_THP can depress the marked increase of NO,ET_1 and lactate in the early stage of reperfusion,and also improve the contents of ATP.Conclusions L_THP have a remarkble protection on cerebral ischemia_reperfusion damage.Its mechanisms may be imvoloved in the influence of L_THP on NO,ET_1 and energy metabolism.

关 键 词：脑缺血 再灌注损伤 左旋四氢帕马汀 能量代谢 一氧化氮 内皮素-1 

分 类 号：R965[医药卫生—药理学]