多发性创伤病人外周血中白细胞介素-12水平的动态变化和临床意义  

Dynamic and clinical study of interleukin-12 level in peripheral venous blood in patients with multiple trauma

作　　者：王维平[1] 李侠[1] 刘大钺 

机构地区：[1]中山医科大学第一附属医院急诊科,广州510080

出　　处：《中国急救医学》2001年第6期323-325,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的　观察多发伤病人外周血中白细胞介素 - 12 (IL - 12 )的动态变化和临床意义。方法　采用酶标法测量36例多发伤病人当天、伤后第 3、7及 14天外周血中IL - 12的水平变化 ,15例正常健康者作为对照。结果　多发伤病人IL -12水平在创伤后各时相点上与对照组比较有显著差异 (P <0 0 5 )。在伤后 7d内 ,ISS≥ 16分组较ISS <16分组有明显增高 (P<0 0 5 )。在伤后并发全身炎症反应综合征 (SIRS)和多器官功能不全综合征 (MODS)的病人 ,IL - 12的水平较非SIRS和MODS的病人显著增高 (P <0 0 5 )。结论　严重创伤后外周血中IL - 12的变化与损伤严重程度相平行。其动态变化监测对伤情的判断可能具有重要的临床意义。Objective To observe the dynamic and clinical study of interleukin-12 levels in peripheral venous blood in patients with multiple trauma.Methods ELISA was applied to measure the IL-12 levels in peripheral venous blood in 36 patients with multiple trauma at the first、third、seventh and fourteenth day.15 healthy persons were taken for the control group.Result The IL-12 levels at every time point in patients with multiple trauma were higher than that of the control group (P<0.05).The IL-12 levels in the group of ISS≥16 were higher than that of the group of ISS<16(P<0.05).The IL-12 levels in patients with Systemic Inflammatory Response Syndrome(SIRS)and Multiple Organ Dysfunction Syndrome(MODS)were higher than that of those without SIRS and MODS(P<0.05).Conclusion The IL-12 levels in peripheral venous blood in patients with multiple trauma have correlation with the injury severity.The dynamic measure of IL-12 change may have important clinical significance.

关 键 词：多发性创伤 白细胞介素-12 全身炎症反应综合征 多器官功能不全综合征 

分 类 号：R641.02[医药卫生—外科学]