庆大霉素-聚酸酐缓释制剂的制备及释药特性  

Preparation of Gentamicin-polyanhydride and Drug Delivery Property Sustained release Bead

作　　者：周志彬[1] 黄开勋[1] 张治国[1] 徐辉碧[1] 

机构地区：[1]华中科技大学化学系

出　　处：《华中科技大学学报（自然科学版）》2001年第4期112-113,共2页Journal of Huazhong University of Science and Technology(Natural Science Edition)

基　　金：武汉市科委攻关项目!(996 0 0 5 12 2G)

摘　　要：以聚 (二聚酸 癸二酸 )共聚物 [P(DA SA) ,wDA∶wSA=5 0∶5 0 ]为药物缓释材料 ,庆大霉素为模型药物 ,采用热熔法制备庆大霉素 -聚酸酐缓释药棒 .初步的制剂稳定性研究表明 ,在室温干燥条件下 ,该缓释药棒具有良好的制剂稳定性 .体外释药结果表明 ,在 37℃时质量分数为 0 .9%的生理盐水体系中 ,该缓释药棒的体外释药时间为 2 5d ,释药动力学符合一级动力学方程 ,其体外释药方程为 :Y =9.182 6 + 6 .6 90 1t -0 .12 72t2 ,R2 =0 .9874.上述结果表明庆大霉素A sustained release bead system consisting of gentamicin dispersed in biodegradable poly (dimmer acid sebacic acid) copolymer[P(DA SA), w DA ∶ w SA =50∶50] is prepared by melt casting. The stability at room temperature and the in vitro release profile in 0.9?% saline buffer at 37?℃ of the bead are determined. The result shows that the formulation has a good stability at room temperature under anhydrous conditions for 6 month. The release of gentamicin from the bead can last 25 days, and the drug release behavior in vitro follows the first order release kinetics, and can be expressed as Y=9.182?6+6.690?1t 0.127?2t 2, R 2=0.987?4 . All the above show that the gentamicin polyanhydride sustained release bead is a significant sustained release system.

关 键 词：庆大霉素 聚(二聚酸-癸二酸) 聚酸酐 药物缓慢释放 缓释制剂 释药特性 

分 类 号：TQ460.4[化学工程—制药化工] TQ465