茵陈素的耐缺氧作用  

Effect of 6,7-dimethexycoumarin on tolerance to anoxia

作　　者：万尧德[1] 陈淑芬[2] 程峰[1] 

机构地区：[1]四川省中药研究所,成都610041 [2]四川省中医药研究院附属医院,成都610041

出　　处：《中国药理学通报》2001年第3期299-302,共4页Chinese Pharmacological Bulletin

摘　　要：目的　观察茵陈素对物理 ,化学因素所致缺氧动物的保护作用。方法　分别采用减压、常压、小鼠断头、化学药品致动物缺氧以及测定整体、离体组织的氧耗量等方法。结果　ip茵陈素 15～ 6 0mg·kg-1能显著提高减压、常压、化学药物所致组织缺氧死亡鼠的存活率或存活时间 ,增加断头鼠头的张口次数 .降低小鼠整体、离体鼠 (心肌 )耗氧量 ,为阐明茵陈素的抗辐射、解化疗毒的作用机制提供实验依据。结论　茵陈素有良好的耐缺氧作用。AIM To study the protection of 6,7 dimethexycoumarin on hypoxic animals. METHODS The effect of 6,7 dimethexycoumarin on survival time and survival rate of mice subjected to hypobaric, normobaric and chemical hypoxia were observed and the oxygen consumption of isolated tissues were measured. RESULTS 6,7 dimethexycoumarin obviously prolonged the survival time and promoted the survival rate of hypoxic mice, increased the mouth opening time of isolated mice and reduced the oxygen consumption of isolated cardiac muscle of mice. This contributes to exploring the mechanism of antiradiation and poison reducing of 6,7 dimethexycoumarin. CONCLUSION 6,7 dimethexycoumarin shows remarkable effect on tolerance to hypoxia in mice.

关 键 词：茵陈素 耐缺氧作用 实验研究 

分 类 号：R285.5[医药卫生—中药学] R282.71[医药卫生—中医学]