适度早期干预对高危儿高胆红素血症的影响  

Effect of Early Proper Intervention on Hyperbilirubinemia of High-Risk Infant

作　　者：翟淑萍[1] 孙翠芳[1] 金月芳[2] 严字斐[2] 钱琦[3] 

机构地区：[1]上海第二医科大学瑞金集团闵行医院儿科,201100 [2]上海第二医科大学瑞金集团闵行医院生化实验室,201100 [3]上海第二医科大学仁济医院儿科

出　　处：《天津医药》2001年第7期390-392,共3页Tianjin Medical Journal

摘　　要：目的:探讨降低基层医院高危围产新生儿(高危儿)高胆红素血症(高胆)发病率的方法。方法:应用口服苯巴比妥、尼可刹米方法,随机对98例高危儿进行早期适度干预,同时测定96例高危儿总胆红素(总胆)变化作对照,并观察两组呼吸、哺乳、体重变化等一般情况。结果:两组间一般情况无显著性差异(P>0.05)。出生后96小时干预组总胆均值低于对照组(P<0.01),144小时两组间总胆均值差异更加显著。对照组发生不同程度高胆者占92.64％,总胆>256.5μmol/L者占76.47％。干预组76.53％的高危儿总胆波动在正常值范围,总胆>256.5μmol/L者占4.08％。结论:肝酶诱导剂早期适度干预可明显降低高危儿高胆发病率,可使其胆红素波动在较合理安全范围,方法简便易于接受。To study the effect of early proper intervention on hyperbilirubinemia of high-risk infants. Methods: One hundred and ninety-four high-risk infants were randomly divided into group I (intervention group, n = 98) and group Ⅱ (control group, n = 96). The infants of group I were properly intervened with oral Phenobarbital and a small dose of Ni-kethamide. The changes of meantime total bilirubin (TBIL), breath, breast-feed and weight between the two groups were observed and compared. Results: There was no significant difference in the changes of breath, breast-feed and weight between the two groups (P>0.05). The mean TBILs after postnatal 96 and 144 hours in group I were significantly lower than those in group Ⅱ (P<0.01). The proportion of TBIL>256.5 μmol/L in group Ⅱ was 76.47% , whereas that in group I was only 4.08% . Conclusion: The early proper intervention by oral liver enzyme inducer may obviously reduce the incidence of hyperbilirubinemia in high-risk infants and keep the TBIL of most high-risk infants in a reasonable and safe level. It is an easy and practical method.

关 键 词：高胆红素血症 危重病 新生儿 发病率 

分 类 号：R722.17[医药卫生—儿科]