鼻息肉中转化生长因子β_1的表达和意义  

Expression and significance of TGF-β_1 in nasal polyps

作　　者：郭剑锋[1] 刘美莲[1] 王向东[2] 陶呼[1] 张呼和[1] 韩德民[2] 诸小侬[2] 

机构地区：[1]内蒙古医学院第一附属医院耳鼻咽喉科,呼和浩特010050 [2]北京市耳鼻咽喉研究所

出　　处：《临床耳鼻咽喉科杂志》2001年第5期206-208,I004,共4页Journal of Clinical Otorhinolaryngology

摘　　要：目的 :探讨转化生长因子β1 (TGF-β1 )在鼻息肉组织中的表达及意义。方法 :将 34例鼻息肉标本及30例中鼻甲粘膜标本行 TGF-β1 免疫组化染色 ,光镜观察。结果 :1TGF-β1 在鼻息肉组织的细胞外基质和固有层浸润细胞的表达明显高于中鼻甲组织 (P <0 .0 1)。 2鼻息肉组织中 TGF-β1 阳性细胞的形态及分布相似于嗜酸性粒细胞 ,二者阳性程度显著相关 (P <0 .0 5 )。 3TGF-β1 阳性表达与鼻息肉的临床分型无关 (P >0 .0 5 ) ,嗜酸性粒细胞浸润程度与鼻息肉临床分型密切相关 (P <0 .0 5 )。结论 :1TGF-β1 可能直接参与鼻息肉的病理变化 ,导致上皮基底膜增厚和基质纤维化。 2嗜酸性粒细胞可能为鼻息肉中 TGF- β1 的主要来源。 3嗜酸性粒细胞在鼻息肉的发病及复发过程中可能发挥重要作用。Objective:To study the expression and significance of transforming growth factor β 1 (TGF β 1) in nasal polyps.Method:Expression of TGF β 1 in nasal polyps from 34 patients and middle turbinates from 30 patients with deviation of nasal septum were prospectively studied with immunohistochemistry.Each tissue section was observed under optical microscope.Result:①The TGF β 1 positivity in extracellular matrix and in cells in the stroma was significantly higher in nasal polyps than in middle turbinates (P< 0.01 ).②The distribution and shape of TGF β 1 expressing cells in nasal polyps was similar to that of eosinophil,their positivities were significantly correlative (P< 0.05 ).③The positivity of TGF β 1 did not correlate with clinical type of nasal polyps (P> 0.05 ),eosinophil infiltration correlated significantly with clinical type of nasal polyps(P< 0.05 ).Conclusion:①The TGF β 1 may contribute to some of the pathologic changes observed in nasal polyps,such as thickening of the epithelial basement membrane and stromal fibrosis.②Eosinophils in nasal polyps represent a major source of TGF β 1.③Eosinophils infiltration may play a prominent role in the development and recurrence of nasal polyps.

关 键 词：鼻息肉 转化生长因子Β1 免疫组织化学 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]