山莨菪碱对豚鼠实验性鼻超敏反应的影响  

Influence of anisodamin on guinea pig experimental nasal hypersensitivity

作　　者：朱志华[1] 董震[1] 杨占泉[1] 

机构地区：[1]吉林大学第三临床医学院耳鼻咽喉-头颈外科,长春130031

出　　处：《临床耳鼻咽喉科杂志》2001年第5期218-220,共3页Journal of Clinical Otorhinolaryngology

摘　　要：目的 :观察山莨菪碱对豚鼠实验性鼻超敏反应的影响。方法 :将实验动物分为正常对照组 ,二异氰酸甲苯脂 (TDI)致敏组 ,利血平组和山茛菪碱组 ,以其鼻部症状记分及鼻粘膜细胞学的变化作为观察项目。结果 :利血平组鼻部症状较 TDI致敏组明显加重 ,鼻粘膜嗜酸性粒细胞明显增高 ,其差异有极显著性意义 (均 P <0 .0 1)。山莨菪碱组鼻部症状明显减轻 ,嗜酸性粒细胞数明显减少 ,与利血平组比较 ,差异有显著性意义 (均 P <0 .0 1)。结论 :以副交感神经兴奋为主的鼻超敏反应性疾病 ,经鼻给予山莨菪碱有一定治疗作用。Objective:To observe the influence of anisodamin on guinea pig experimental nasal hypersensitivity.Method:Experimental animals were divided into normal control group, TDI group,reserpine group and anisodamine group.The scores of symptom of nose and the cytologic changes of nasal mucosa were parameters of observing.Result:The nasal symptom of reserpine group was significantly stronger than the TDI group,and the eosinophilia evidently increased (both P< 0.01 ).The nasal symptom of the anisodamine group reduced and the eosinophilia decreased.It is significantly difference between the TDI group and the reserpine group (both P< 0.01 ).Conclusion:Anisodamine may play a role in therapy of the experimental nasal hypersensitivity with hyperfuction of parasympathetic nerve.

关 键 词：鼻超敏反应 山莨菪碱 副交感神经 实验研究 豚鼠 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]