利用超临界CO_2制备α-细辛醚及布洛芬微细颗粒  

Study on the process of formation of fine α-asarone and ibuprofen particle by rapid expansion of supercritical solution

作　　者：陈兴权[1] 赵天生 于慧杰 郁威[3] 

机构地区：[1]宁夏大学能源化工自治区重点实验室,宁夏银川750021 [2]北京双鹤现代医药技术有限责任公司,北京100020 [3]华东理工大学化学工程研究所,上海200237

出　　处：《宁夏大学学报（自然科学版）》2001年第2期155-157,共3页Journal of Ningxia University(Natural Science Edition)

摘　　要：用超临界CO2 法制备了药物α 细辛醚和布洛芬的微细颗粒 ,考察了膨胀压力、膨胀前温度、沉析室温度、喷嘴直径等因素对颗粒平均直径的影响 .对制备的微粒分别用XRD 。Formation of fineα-asarone and ibuprofen particle by rapid expansion of supercritical solution , effects of technique condition such as expansion pressure,preexpansion temperature,precipitation temperature,nozzle diameter to fine and uniform particles were investigated,respectively. The characteristics of fine ibuprofen particles was analysed by XRD,SEM.

关 键 词：Α-细辛醚 布洛芬 微细颗粒 药物制备 超临界二氧化碳 膨胀压力 药物细化 

分 类 号：TQ463.3[化学工程—制药化工] TQ460.64