含脲基片段不对称方酰胺、异方酰胺的合成  

THE SYNTHESIS OF THE ASYMMETRIC SQUARIC AMIDES AND ISOSQUARYLIUM AMIDES WITH UREIDO

作　　者：李鸿波[1] 李聚才[1] 陈益钊[1] 

机构地区：[1]四川大学化学学院,成都610064

出　　处：《四川大学学报（自然科学版）》2001年第4期532-539,共8页Journal of Sichuan University(Natural Science Edition)

摘　　要：以氨甲酰类氮氧方酸 1和 (N 脂肪基 )氮氧方酸正丁酯 4为原料 ,分别与芳伯胺和脲类化合物反应 ,实现了不对称取代的方酰胺 6a～ 6l,7a～ 7c和异方酰胺 3a～ 3s的合成 ,共得 34个新化合物 。The asymmetric squaric amides 6a～6l,7a～7c and asymmetric isosquarylium amides 3a～3s were smoothly prepared by the reaction of mono carbamoyl amide of squaric acid (MCASQA, 1) with primary arylamines and (N aliphatic) n butyl nitroxosquarate 4 with urea or its derivatives under the moderate condition. Thirty four new compounds were obtained. The common marked characteristic of the structure of these compounds is that the molecule has the ureido with physiological activity.

关 键 词：氨甲酰类氮氧方酸 (N-脂肪基)氮氧方酸正丁酯 芳伯胺 脲 方酰胺 异方酰胺 脲基片段 合成 

分 类 号：O623.626[理学—有机化学]