血浆LPO、TXA_2/PGI_2平衡与糖尿病微血管病变的关系  

Studies, on interrelation of plasma LPO,TXA_2/PGI,and diabetic microangiopathy

作　　者：柴国禄[1] 王维忱 刘晶砾[1] 张建华[1] 黄丛春[1] 郭军[1] 

机构地区：[1]佳木斯医学院附属医院内分泌科

出　　处：《佳木斯医学院学报》1991年第2期104-107,179,共4页

摘　　要：作者测定了50例正常人,94例糖尿病患者血浆过氧化脂(LPO)及血浆6—酮—前列腺素 F_1α(6—酮—PGF_1α)和血栓素 B_2(TXB_2)的浓度,并分析血浆 LPO、TXB_2/6—酮—PGF_1α比值与糖尿病微血管病变的关系。结果有微血管病变糖尿病患者血浆 LPO 显著高于无微血管病变糖尿病患者。有微血管病变糖尿病患者血浆 TXB_2/6—酮—PGF_1α比值显著高于对照组,无微血管病变糖尿病患者两者比值与对照组相比无显著差异。有微血管病变糖尿病患者血浆 LPO 与 TXB_2/6—酮—PGF_1α比值呈正相关。提示有微血管病变并发症的糖尿病患者存在血浆 LPO 升高和循环 TXA_2与前列环素 PGI_2的比例失衡.Plasma concentration of LPO 6—keto—PGP_1α and TXB_2 were measured in 50 cases of control and 94 diabetics.The correlation between diabetic mi- croangiopathy and plasma LPO TXB_2/6—keto-PGF_1α was analysed.Diabetics were divided into three groups according to the changes in retina and renal function.Group A,diabetics without microangiopathy;Group B,diabetics with slight microangiopathy;and group C,diabetics with severe microangiopathy.The results showed that the plasma LPO was higher in B and C groups than in the controls and group A and that the ratio of TXB_2/6-keto-PGF_1α was higher in B and C groups than in the controls.Group A patients bed aligh.ly higher level of the ratio than the controls without significant difference.A posi.ive correlation was found between plasma LPO and ra(?)io of TXB_2/6-ke.o-PGF_1α in diabetics with microangiopathy.Our results suggest that there is an increase in plasma LPO and the TXB,and 6-keto-PGF α imbalance in diabetics with miereangiopathy;and this change might be of more significance in the patho- genesis of diabetic microangiopathy compared to control.

关 键 词：糖尿病 微血管病变 过氧化脂 

分 类 号：R587.102[医药卫生—内分泌]