汉防已甲素对四氧嘧啶糖尿病大鼠高血糖的预防作用  

Preventive effect of tetrandrine on diabetic hyperglycemia induced by alloxan in rats

作　　者：孙桂荣[1] 魏英杰[1] 张桂芳[1] 张景祥[1] 杨殿生[1] 

机构地区：[1]佳木斯医学院生理教研室

出　　处：《佳木斯医学院学报》1991年第4期271-273,357,共3页

摘　　要：本研究以血糖为检测指标,观察了汉防己甲素对四氧嘧啶糖尿病大鼠高血糖的预防作用。结果表明:①预先给予不同剂量的汉防己甲素,皆可不同程度地防止四氧嘧啶升高血糖的作用,其预防效果随剂量的增加而增强。②预先给予汉防己甲素(100mg/kg)预防组和注射四氧嘧啶后24h给予汉防己甲素(100mg/kg),预防组于注射四氧嘧啶(0天)后第2、3、5、7天的血糖浓度与对照组同天血糖比较均明显降低(P<0.01)。结论:注射四氧嘧啶前后一定时间给予汉防己甲素均可预防四氧嘧啶致高血糖作用的发生。动态观察1周,预防组血糖浓度稳定,无升高趋势。The preventive effect of tetrandrine (TET)on alloxan-induced hyperglycemia in rats was observed by assay for the blood sugar. The results suggested, that different doses TET infused at 1.5h prior to alloxan (50mg/kg ) iv injection innibited significantly increase of blood sugar resulted from alloxan and the preventive effect enhance with the increase of dose, and also that TET (100mg/kg) at 1.5h prior to alloxan iv injection and the infusion of TET (100mg/kg ) at 24h after the injection of alloxan both decreased the blood sugar level for a week compared with the blood sugar of control group in same day (P<0.01).

关 键 词：汉防己甲素 四氧嘧啶 糖尿病 血糖 

分 类 号：R977.15[医药卫生—药品]