糖障明对糖尿病大鼠晶状体水溶性蛋白质的影响  

The effect of tangzhangming (糖障明) on water soluble proteins in lens of rats with diabetic mellitus

作　　者：谢学军[1] 李萍[2] 肖丹[3] 黄秀蓉[1] 杜联[4] 李翔[1] 李瑞荃 

机构地区：[1]成都中医药大学眼科教研室,四川610075 [2]成都中医药大学科技处 [3]成都中医药大学制剂教研室 [4]成都中医药大学生理教研室 [5]SawraUniversityofOrientalMedicine

出　　处：《中国中医眼科杂志》2001年第3期128-130,共3页China Journal of Chinese Ophthalmology

基　　金：国家中医药管理局科研课题基金 (95A2 619)

摘　　要：目的　探讨糖障明对糖尿病性白内障的治疗作用及其机制。方法　以链脲佐菌素造成糖尿病动物模型 ,用凝胶过滤法测定晶状体组织中水溶性蛋白的相对百分含量。结果　与正常对照组相比 ,阴性对照组糖尿病大鼠晶状体组织中α晶状体蛋白相对百分比含量显著升高 ,β和γ晶状体蛋白相对百分比含量显著下降 (P <0 0 1 )。糖障明中药治疗组糖尿病大鼠晶状体组织中α晶状体蛋白相对升高和 β及γ晶状体蛋白相对减少的程度均明显低于阴性对照组和降糖灵对照组 (P <0 0 5 ,0 0 1 )。结论　糖障明具有减轻糖尿病大鼠晶状体蛋白异常代谢的作用 。OBJECTIVE To investigate effect of tangzhangming (糖障明) in treatment of diabetic cataract and its therapeutics mechanism METHODS The animal model of diabetes was introduced by streptozotocin The relative percentage quantities of water soluble proteins in lens were detected with gel filtration RESULTS Compared with normal control group, the relative percentage quantity of α crystalline was increased distinctly, and β and γ crystallin were decreased markedly in negative control group ( P <0 01) The incremental degrees α crystalline and decreased degrees of β and γ crystallin were significantly lower in treated groups with tangzhangming than those in both negative control group and treated control groups with phenformin ( P <0 05～0 01) CONCLUSION Tangzhangming could alleviate the abnormal metabolism of crystallin in experimental diabetic rats, and it might be relative to therapeutic mechanism for inhibiting the formation of diabetic cataract

关 键 词：糖障明 糖尿病 晶状体蛋白 

分 类 号：R259.872[医药卫生—中西医结合]