急性一氧化碳中毒患者血清β-内啡肽水平及临床意义  

The clinical significance of measuring serum β-endorphin in patients with acute carbon monoxide poisoning

作　　者：荆晓明[1] 董芸[1] 宋文忠[2] 王晓梅[1] 刘晓岗[1] 朱旭光[1] 

机构地区：[1]四川省人民医院急救中心内科,成都610071 [2]四川省人民医院核医学科,成都610071

出　　处：《医学科技》2001年第2期3-5,共3页

摘　　要：目的:探讨急性一氧化碳中毒患者血清β-内啡肽浓度变化及临床意义。方法:用放射免疫法测定32例急性一氧化碳中毒患者β-内啡肽浓度并与25例健康者进行比较。结果:急性一氧化碳中毒患者在治疗前、治疗后24小时的β-内啡肽水平较对照组显著升高(P<0.05);中毒组中治疗后24小时β-内啡肽水平与治疗前比较有下降(P<0.01)。结论:急性一氧化碳中毒导致大量释放β-内啡肽并持续高水平;同时,高水平β-内啡肽可导致继发性脑损伤。Objective: To investigate the changes of serum β-endorphin in patients with acute mon-oxide poisoning and its clinical significance. Methods: The serum β-endorphin concentration was mea-sured by radioimmunoassy poisoning before treatment, 24 hours and 48 hours after treatment. Results:The levels of β-endorphin were significantly increased the poisoning group before treatment, 24 hours incomparison with control group (P<0.05), the levels of β-endorphin in the poisoning group was de-creased 24 hours after treatment in comparison with that before treatment (P<0.01). Conclusion:Acute carbon monoxide poisoning may result in releasing of β-endorphin largely and maintain the higherlevel, mean while the higher level of β-endorphin may give rise to secondary cerebral injury.

关 键 词：一氧化碳中毒 Β-内啡肽 治疗 

分 类 号：R595.1[医药卫生—内科学]