尿β_2-MG对2型糖尿病亚临床糖尿病肾病诊断价值的探讨  

Clinical Value of Urine Alb, β_2-MG RIA for Diagnosis of NIDDM Subclinical Diabetic Nephropathy

作　　者：汤建林[1] 赵立群[1] 李玉莹[1] 汪慧如[1] 

机构地区：[1]云南省大理州医院(大理医学院非直属附属医院)核医学科,671000

出　　处：《医学理论与实践》2001年第6期485-487,共3页The Journal of Medical Theory and Practice

摘　　要：目的:探讨尿β_2-MG对2型糖尿病(DM)亚临床糖尿病肾病(DN)的诊断价值。方法:对尿常规、血尿素氨 (BUN)、血肌酐(Cr)正常的63例2型DM患者(亚临床DN组)分别进行血、β_2-MG和尿Alb放射免疫测定(RIA)。 结果:剔除3例血β_2-MG>4.5mg/L患者后分析发现,亚临床DN组尿β_2-MG、Alb显著高于正常对照组(P<0. 001);尿Alb阳性率与尿β_2-MG阳性率无显著性差异(P>0.05);尿β_2-MG与尿Alb检测结果显著正相关(r=0. 495,n=60,P<0.001)。结论:DN时肾小球、肾小管均易受损,且存在着密切的正相关关系,尿β_2-MG是诊断早期 DN的一项重要指标,与Alb联合检测,可以提高DN的早期诊断率,并能对DN时肾小球和肾小管受损的部位及程 度作出判断。Objective : To observe the clinical value of urine β2 -MG RIA for diagnosis of NIDDM subclinical diabetic ne-phropathy and study correlation between Alb and β2-MG. Methods: The serum and urine β2- microglobulin (β2-MG) and urine albumin (Alb)of 63 NIDDM patients were measured by radio-immunoassay(RIA), whose routine urinalysis, serum urea nitrogen (BUN) and creatinine (Cr) were normal (subclinical diabetic nephropathy group). Results:with exclusion of 3 NIDDM patients whose serum β2-MG exceed 4. 5mg/L, urine β2-MG and Alb of subclinical diabetic nephropathy group were significantly higher ghan those of control group (P<0.001). No significant difference in positive rate was observed between the urine Alb and β2-MG(P>0.05). There was significantly positive correlation between the β2-MG and Alb(r = 0.495, n = 60,P<0.001). Conclusion: When diabetic nephropathy occurs, both glomerule and uriniferoustabule are easily injured correspondingly. Urine β2 -MG is a sensitive index for early DN, and combined with RIA of ft -MG and Alb will contribute to detect DN early, and judge injured position and degree of DN.

关 键 词：Ⅱ型糖尿病 亚临床 糖尿病肾病 Albβ-MG 诊断 

分 类 号：R587.104[医药卫生—内分泌]