卡泊姆与羟丙基甲基纤维素在体内外与大鼠胃肠粘膜粘附性的考察  

INVESTIGATION OF THE BIOADHESION OF CARBOPOL AND HYDROXYPROPYL METHYLCELLULOSE TO RAT GASTROINTESTINAL MUCOSA IN VIVO AND IN VITRO

作　　者：张志荣[1] 付劼[1] 黄园[1] 段逸松[1] 

机构地区：[1]四川大学药学院,四川成都610041

出　　处：《药学学报》2001年第7期543-546,共4页Acta Pharmaceutica Sinica

基　　金：国家杰出青年科学基金资助项目 (3 992 5 0 3 9)

摘　　要：目的　为口服缓释制剂的处方设计提供理论依据。方法　体外评价用最大粘附力作指标 ,体内评价以其在胃的排空速率和一定时间内到达小肠的距离为指标。考察不同粘度规格的卡波姆 (Cb)和羟丙基甲基纤维素(HPMC)与大鼠胃肠粘膜之间的生物粘附性。结果　与生物粘膜之间的粘附力粘度低的材料大于粘度高的材料 ;而胃肠道转运速度则粘度高的材料比粘度低的材料慢。结论　粘附材料与生物粘膜之间的粘附力与其在大鼠胃肠道内的转运速度无相关性 ;体内研究结果表明 ,Cb934在所考察的粘附材料中有最佳的生物粘附性 。AIM To investigate bioadhesion of carbopol and hydroxypropyl methylcellulose of different viscosity grade to rat gastrointestinal mucosa. METHODS The maximum adhesion force has been adopted as an index of adhesive evaluation in vitro , gastro emptying rate and migrating length in intestine have been adopted as an index of adhesive evaluation in vivo . RESULTS In vitro adhesion studies indicated that the adhesive force of low vicosity materials was stronger than that of high vicosity materials, while the transferation rate of high vicosity materials is significantly higher compared to that of low vicosity materials in vivo . CONCLUSION Adhesive force of materials gives no correlation with rate of the materials in rat; Cb934 have the optium bioadhesion among the studied materials and can be used as the preferred adjuvant in oral bioadhesion preparation.

关 键 词：卡波姆 羟丙基甲基纤维素 生物粘附 大鼠 缓释剂 

分 类 号：R944.9[医药卫生—药剂学]