溶剂和氮酮对噁丙嗪透皮速率的影响  

Effects of solvents and Azone on percutaneous penetration of oxaprozin across rat skin

作　　者：郭宏[1] 高金波[1] 潘卫三[2] 

机构地区：[1]佳木斯大学,佳木斯154002 [2]沈阳药科大学,沈阳110015

出　　处：《黑龙江医药科学》2001年第3期8-8,10,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的：研究溶剂与氮酮对恶丙嗪渗透性的影响。方法：分别采用乙醇和丙二醇为溶剂，利用离体大鼠皮肤和Valia-Chien水平扩散池，测定恶丙嗪的经皮渗透速率。结果：氮酮在丙二醇溶液中具有明显的促渗作用。结论：恶丙嗪的体外渗透符合零级动力学过程。Objective: To study the effects of solvents and Azone on percutaneous penetration of oxaprozin across the rat skin. Methods: The percutaneous rates in the steady state of oxaprozin in the various solvents across the rat skin in vitro were determined using Valia-Chien diffusion cell. Result: The Azone-propylene glycol had obviously synergistic effects. Conclusion: The transedermal osmotic process of oxaprozin fitted to a zero-order kinetic mechanism.

关 键 词：氮酮 透皮速率 恶丙嗪 溶剂 乙醇 丙二醇 

分 类 号：R971.1[医药卫生—药品]