甲苯达唑驱治鞭虫及其它肠线虫感染的疗效观察  

Observation on Efficacy of Mebendazole in the Treatment of Trichuri and Other Intestinal Nematode Infections

作　　者：马杏宝[1] 黄德生[1] 蔡黎[1] 张宝秀[1] 傅英华[1] 葛宏妍[1] 

机构地区：[1]上海市疾病预防控制中心,上海200031

出　　处：《中国公共卫生》2001年第8期698-699,共2页Chinese Journal of Public Health

摘　　要：目的　观察相同剂量不同疗程的甲苯达唑对鞭虫感染者驱虫效果。方法　将 42 0例以鞭虫感染为主的肠线虫病患者分成 3组 ,其中 2组甲苯达唑总剂量 80 0mg ,2天 (A组 )、4天(B组 )分服 ,另一组阿苯达唑总剂量 6 0 0mg ,2天分服为对照 ;于服药前和服药后 2周和 4周分别以改良加藤厚涂片法粪检考核疗效。结果　治毕 2周 ,甲苯达唑 4天疗法组鞭虫卵阴转率 (97 2 0 % )高于 2天疗法组 (88 0 4% ) (P <0 0 5 ) ,但治后4周虫卵阴转率相同 ;阿苯达唑 2天疗法组 (72 45 %～76 14% )较前 2组低 (P <0 0 0 1和P <0 0 1)。虫卵减少率 3组均高于 95 % ,3组鞭虫卵未阴转者治后平均EPG较治前均呈减少趋势。蛔虫卵治后 4周的阴转率为 91 6 7%～96 43 % ,3组间无差异。 3个组的药物副反应均轻微短暂。结论　甲苯达唑 80 0mg 2天、4天疗法驱治鞭虫的疗效均达 91%以上 ,明显优于阿苯达唑。Objective To observe the anthelmintic efficacy of different therapeutic course of mebendazole on trichuriasis.Methods Four hundred and twenty patients with single trichuris infections or mixed infection with ascaris or hookworm in Shanghai suburb were randomized into 3 groups and treated with 800mg mebendazole in differnet course.(Group A:A daily dose of 200 mg mebendazole for 4 days;Group B:A daily dose of 400 mg mebendazole for 2 days;Group C:A daily dose of 300mg albendazole for 2 days as control).Stool reexamination by Kato-Katz was done in 2 week and 4 week after treatment.Results The rate of egg negative conversion of group A(92 07%) was higher than that of group B(88 04%, P <0 05) after being treated for two weeks,but no difference at 4 weeks;the date of group C(72 45%-76 14%) was lower than the group A and B( P <0 01 and P <0 01).The rate of egg reduction rate after treatment was all above 95% in 3 groups.The cure rate against Ascaris of both drugs being 91.67%-96.43% 4 week afte treatment and no statistic difference in 3 groups.The side effects were few and mild.Conclusion The efficacy of 800mg mebendazole in 2 day or 4 day course was more than 91% on Trichuriasis.Mebendazole had better effect on expelling trichruis than albendazole.

关 键 词：甲苯达唑 鞭虫 蛔虫 药物疗法 治疗 疗效 

分 类 号：R978.61[医药卫生—药品] R531.7[医药卫生—药学]