硒、锗对羟自由基的联合清除作用  

Studies on the hydroxyl free radical-scavenging effect of combined selenium and germanium

作　　者：吴志刚[1] 陈学敏[1] 杨克敌[1] 夏涛[1] 刘四海[1] 谢文[1] 

机构地区：[1]华中科技大学同济医学院,武汉430030

出　　处：《卫生研究》2001年第4期208-210,共3页Journal of Hygiene Research

基　　金：国家自然科学基金 (No.3 92 70 5 79)

摘　　要：在以FeSO4 还原型辅酶Ⅱ引发大鼠肝微粒体产生羟自由基体系中 ,加入不同剂量Na2 SeO3、Ge 132和Na2 SeO3与Ge 132混合物 ,以N 特丁基 2 苯硝酮作为捕获剂 ,采用电子自旋共振技术检测羟自由基。结果表明在本实验剂量范围内 ,随着Na2 SeO3,Ge 132和其混合物浓度增加而羟自由基清除率提高 ,且在低剂量条件下 ,Na2 SeO3与Ge 132有协同增效清除作用。The effect of selenium, carboxyethyl germanium sesquioxide (Ge 132) and the combination of selenium and Ge 132 on the production of hydroxyl free radical in liver microsomes of rats treated with Fe 2SO 4 NADPH system was studied with electron spin resonance technique (ESR). The results showed that the production of hydroxyl free radical was decreased significantly by adding selenium, Ge 132 and combined selenium and Ge 132, indicating a direct scavenging effect on hydroxyl free radical. It was also observed a enhanced scavenging effect at the low concentration of combined selenium and Ge 132.

关 键 词：羟自由基 硒 锗-32 电子自旋共振 清除 

分 类 号：R977.9[医药卫生—药品] Q554.6[医药卫生—药学]