运动性与病理性左室肥厚心肌力学的对比研究  

A Comparative Study on Myocardial Mechanics between Exercise-induced and Pathological Left Ventricular Hypertrophy in Rats

作　　者：李春跃[1] 郭建增[1] 韩补生[1] 

机构地区：[1]内蒙古医学院生理教研室,呼和浩特010059

出　　处：《中国运动医学杂志》2001年第3期241-243,265,共4页Chinese Journal of Sports Medicine

摘　　要：目的：为揭示长期运动训练与高血压病所致两类心肌肥大的联系与区别，对二者进行心肌力学分析。方法：以大鼠为研究对象，分别用腹主动脉缩窄加盐负荷法制作高血压性心肌肥大模型、游泳训练制作运动性心肌肥大模型。测定动物的一般性指标：收缩压、舒张压、全心重、心室重和左室重。借助八导生理记录仪和计算机分别在基础状态和给去甲肾上腺素状态下对两种动物模型的在体心脏作心肌力学测量。结果：一般性指标，高血压组收缩压和舒张压显著高于其它组（Ｐ＜０．０１）。高血压组和运动训练组的全心重、心室重和左室重显著高于对照组（Ｐ＜０．０１），尤以运动训练组明显。心肌力学指标，在基础状态下：高血压组和运动训练组与对照组相比±ｄＰ／ｄＴｍ、ｄＰ／ｄＴ／ ＩＰ、Ｖｃｅ４０、“心力环”Ｌ０－Ｌ４等心肌力学指标升高，有显著性差异。高血压组的上述各项指标均低于运动训练组（Ｐ＜０．０１）。在给去甲肾上腺素刺激状态下，对照组、运动训练组和高血压组的心肌力学指标均表现为升高；运动训练组Ｖｐｍ、Ｖｍａｘ、“心力环”Ｌ０－Ｌ４的升高比高血压组明显，两组间有显著性差异（Ｐ＜０．０１）。结论：在基础状态下，运动性心肌肥大与高血压病理性心肌肥大心肌舒缩功能均表现为增强。Objective: Left ventricular hypertrophy(LVH) or myocardial hypertrophy was the common consequence of chronic hypertension and long-term exercise training. Making myocardial mechanics researches on it will contribute to bringing to light the differences and connections between this two kinds of myocardial hypertrophy. Methods: We took abdomen aortic constriction rats and swimming trained rats as hypertensive and exercise trained animal model respectively, and made a myocardial mechanics measure to the in vivo heart of this two kinds animal model. The myocardial mechanics parameters included the function of myocardial systolic, such as +dP/dTmax, dP/dT/IP, Vpm, Vmax,Vce40, L1-L3 and the function of myocardial diastolic, -dP/dTmax and L4 were compared in basal state, and given extrinsic NE. Results: The heart of hypertensive rats which had subjected to hypertension for 4 weeks had a higher function rats in systolic and diastolic compared with that of sham operation rats in basal state, parameter ±dP/dTmax, dP/dT/IP, Vce40, P-dP/dT/P loop show a obvious difference (p＜0.01). The same discrepancy could also be found between exercise trained group and normal control group. When subjected to the stimuli of extrinsic NE, the hearts of the hypertensive group manifested a decreased response and cardiac reserve,which constituted a striking contrast with exercise group, which showed enhanced function in the same circumstance. Conclusion:The systolic and diastolic function in exercise trained and pathological myocaldial hypertrophy enhanced in basal state but latter less than former. The responsiveness and cardiac reserve in pathological myocardial hypertrophy was less than that in exercise trained. The myocardial hypertrophy in exercise trained rats was a kind of adaptive reaction.

关 键 词：心肌肥大 高血压 运动 心肌力学 

分 类 号：R873[医药卫生—运动医学]