实验性持续神经根受压减压后早期神经变化的研究  

Early Changes of Nerve Roots After Decompression Following Continuous Compression

作　　者：王传疆[1] 原泉[2] 王欢[2] 王海义[2] 

机构地区：[1]中国医科大学第一临床学院外科,沈阳110001 [2]中国医科大学第二临床学院骨科,沈阳110001

出　　处：《中国医科大学学报》2001年第4期261-263,共3页Journal of China Medical University

摘　　要：目的 :研究持续性受压的脊神经根在减压后早期的变化。方法 :成年家猫 2 1只随机分成 3组 ,制成右侧L7神经根持续性受压的模型 ,分别于术后 2周 (I组 ) ,4周 (II组 ) ,6周 (III组 )再次进行减压手术 ,制成右侧L7神经根减压的模型。减压手术后观察 6周 ,并取正常的左侧作为对照组 ,进行神经电生理学检测和组织学观察。结果 :脊神经根在持续受压 2周进行减压手术后 ,神经传导速度和阈强度明显恢复。而持续受压 4及 6周减压手术后神经传导速度和阈强度恢复不明显。各组神经根组织学改善无明显差异。结论 :脊神经根受压时间是机械性压迫所致的神经根病损中一个重要因素 ,临床减压手术应在脊神经受压早期未超过Objective: Our aims were to study early changes of spinal nerve roots after decompression following continuous compression. Methods: Animal models of right L 7 nerve roots with continuous compression were made in 21 adult cats. All cats were divided into 3 groups randomly. Decompression of right L 7 nerve roots was performed 2 weeks, 4 weeks, and 6 weeks after compression to establish the models. Electrophysiologic and histological examination were taken 6 weeks after the decompression. The left L 7 nerve roots were used as control group. Results: The nerve conduction velocity and threshold recovered significantly when the decompression was performed 2 weeks after continuous compression. There was no obvious recovery of nerve conduction velocity and threshold when the decompression was performed 4 and 6 weeks after continuously compression. There is no significant difference in neurohistopathologic changes in all groups. Conclusion: The time factor is an important factor in continuously compressed spinal nerve root disease. Decompression should be done in the early 2 weeks after the eperation.

关 键 词：脊神经根 持续受压 减压手术 早期神经变化 

分 类 号：R651[医药卫生—外科学]