血浆内皮素和心钠素与维持性血液透析患者高血压关系的研究  

The Relationship Between the Concentrations of Plasma Endothelin-1, Natriuretic Peptide and Hypertension in Maintenance Hemodialysis Patients

作　　者：李曼[1] 严海东[1] 孙雪峰[1] 郑晓勇[1] 钱正子[1] 

机构地区：[1]中国医科大学第一临床学院肾内科

出　　处：《中国医科大学学报》2001年第4期293-295,共3页Journal of China Medical University

摘　　要：目的 :探讨血浆内皮素 (ET)和心钠素 (ANP)在维持性血液透析患者高血压中的作用。方法 :尿毒症患者分为维持性血液透析不使用促红细胞生成素 (EPO)组、维持性血液透析使用EPO组及尿毒症非透析组 ,以上 3组各自分为高血压组和血压正常组。另设健康对照组。应用放射免疫法检测血浆ET 1和ANP水平。结果 :所有尿毒症患者血浆ET 1和ANP水平均高于健康对照组 ,维持性血液透析使用EPO组血浆ET 1和ANP水平高于维持性血液透析不使用EPO组 (P <0 .0 5 ) ;各组中高血压亚组的血浆ET 1水平及ET 1/ANP比值均高于其相应的血压正常组 ( P <0 .0 5 ) ,而血浆ANP水平高低不等。各组血浆ET 1和ANP间无相关性。结论 :维持性血液透析患者的高血压同血浆ET 1水平升高以及ET 1和ANP比值的增大有密切关系。Objective: Our purpose was to study the effects of endothelin (ET) and aortic natriuretic peptide (ANP) on hypertension in patients with maintenance hemodialysis. Methods: Patients with uremia were classified into hemodialysis and non hemodialysis groups, which were divided into two subgroups according to their arterial blood pressure, hypertension subgroup and normal arterial blood pressure subgroup. Patients in hemodialysis group were further divided into EPO group and non EPO group. Healthy volunteers were as control. Plasma ET 1 and ANP were detected with radioimmunol method. Results: Both plasma ET 1 and ANP of uremia patients were more than those of control group. Plasma ET 1 and ANP of non-hemodialysis group were less than the mean value of hemodialysis group. The ET 1 and ANP of hemodialysis EPO group were more than those of hemodialysis non EPO group. The ratio of plasma ET 1/ANP in every subgroup with hypertension was more than that of their correspondent subgroup with normal blood pressure, but ANP diversed. Plasma ET 1 and ANP of different groups showed no apparent correlation. Conclusion: There is a correlation between the blood pressure of patients with maintenance hemodialysis and plasma ET 1, ET 1/ANP ratio.

关 键 词：血液透析 高血压 内皮素-1 心内素 

分 类 号：R544.1[医药卫生—心血管疾病] R459.5[医药卫生—内科学]