干扰素治疗丙型肝炎过程中血清肝纤维化指标的变化  

Changes of the Serum Markers for Hepatic Fibrogenesis During Treatment of Interferon Alfa for Chronic Hepatitis C

作　　者：穆桂玲[1] 吕飒[1] 孙国军[2] 舒波[1] 刘沛[1] 

机构地区：[1]中国医科大学第二临床学院传染科,沈阳110004 [2]鞍山市鞍钢曙光医院

出　　处：《中国医科大学学报》2001年第4期309-310,314,共3页Journal of China Medical University

摘　　要：目的 :观察干扰素治疗慢性丙型肝炎过程中血清肝纤维化指标的改变。方法 :应用ELISA法对 4 4例慢性丙型肝炎病人在干扰素治疗开始时、结束时和停药后 6个月检测血清透明质酸 (HA)、层粘连蛋白 (LN) )、Ⅲ型前胶原肽 (PⅢP)和Ⅳ型胶原 (C Ⅳ )。结果 :干扰素治疗完全应答组 (CR S)和完全应答伴反跳组 (CR R)治疗前血清HA、LN、PⅢP和C Ⅳ水平低于无应答组 (NR) ,差异显著 (P <0 .0 5 ) ;CR S组干扰素治疗后血清HA、LN、PⅢP和C Ⅳ水平明显下降 (P <0 .0 5 ) ;CR R组和NR组干扰素治疗后血清肝纤维化指标无明显下降 ,甚至升高。结论 :应用干扰素治疗丙型肝炎时 ,随着肝内炎症的改善 ,血清肝纤维化指标的水平明显下降 ,对慢性肝炎肝纤维化的发生和发展有改善作用。Objective: Our aim was to estimate the changes of serum markers in fibrogenesis during treatment of interferon alfa for chronic hepatitis C. Methods: Forty four patients with chronic hepatitis C received intramuscular injection of 3×10 6 units of interferon alfa for 6 months.The serum levels of hyaluronate(HA),laminin(LN) ,type Ⅲ procollagen peptide(PⅢP),and type Ⅳ collagen(C Ⅳ)were measured before (0 month),at the end of interferon alfa therapy (6 months),and the 6th month after the therapy (12 months) in these patients by using enzyme linked immunosorbent assay(ELISA).Results: The serum levels of HA,LN,PⅢP, and C Ⅳ in sustained complete response (CR S) and complete response with rebound (CR R) groups were significantly lower than those levels in nonresponse (NR) group (P<0.05).The serum levels of HA,LN,PⅢP, and C Ⅳ levels in CR S significantly decreased after the therapy(P<0.05). These levels remained abnormally high in the CR R and NR groups. Conclusion: Interferon therapy could lower the levels of the markers in hepatic fibrogenesis with the improvement in symptoms in hepatic inflammation.

关 键 词：干扰素 慢性丙型肝炎 肝纤维化 药物疗法 治疗 

分 类 号：R512.63[医药卫生—内科学] R575.2[医药卫生—临床医学]