美蔷薇果实化学成分的研究  

Chemical Constituents from the Fruit of Rosa bella Rehd. et Wils.

作　　者：陈封政[1] 彭树林[1] 丁立生[1] 何永华[1] 王明奎[1] 

机构地区：[1]中国科学院成都生物研究所,四川成都610041

出　　处：《中国中药杂志》2001年第8期549-551,共3页China Journal of Chinese Materia Medica

基　　金："九五"中国科学院资源与生态环境研究重点资助项目

摘　　要：目的 :研究山西产美蔷薇果实的化学成分及其活性。方法 :溶剂提取 ,色谱分离 ,1H ,13 C NMR或与标准化合物比较鉴定其结构 ;离体蟾蜍心脏试验其心肌收缩力 ;酶学法测定血清中血脂含量。结果 :分离并鉴定了 7个化合物 ,pomolicacid ,3 O β D 葡萄糖 (6 O 对羟基反式香豆酰基 ) 山萘素苷 ,蔷薇酸 ,胡萝卜苷 ,槲皮素 ,齐墩果酸 ,β 谷甾醇 ;甲醇提取物 (0 .4～ 1.0mg·ml-1)有明显强心作用 ,40 0mg·kg-1对正常大白鼠血清胆固醇、高密度脂蛋白和甘油三脂的含量均无明显影响。结论Objective:To investigate the chemical constitu en ts from the fruit of Rosa bella and its bioactivity.Method:The compounds were isolated from the methanol extract by column chromatography , then identified by 1 H, 13 C NMR and by comparison with authentic samp les. The unorganized hoptoad heart was used for testing the contracting force of cardiac muscle and enzymology for measuring the bloody lipid of serum in rats .Result:Seven compounds were isolated and identified as pomoli c acid, tiliroside, euscaphic acid, daucosterol, quercetin, oleanolic acid and β-sitosterol, respectively. In the concentration of 0.4～1.0 mg·ml -1 ,the methanol extract had obvious cardiotonic effect. While at 400 mg·kg - 1 , there are no obvious effect to the TC, HDL-ac and TG of serum in rats.Conclusion:The isolated compounds may be the active components of this plant.

关 键 词：美蔷薇果实 化学成分 强心作用 

分 类 号：R284.1[医药卫生—中药学]