急性过敏性紫癜免疫功能的改变及中西医结合治疗对其调节作用  

Immune Functional Changes in Patients of Acute Henoch-Schonlein Purpura and Regulatory Effect of Integrated Traditional Chinese and Western Medicine on It

作　　者：贾文翠[1] 张有成[1] 魏阿平[1] 梁桂珍[1] 郭卫平[1] 郜贺荣[1] 张玉芬[1] 张英茹[1] 

机构地区：[1]河北省张家口医学院第一附属医院,河北075000

出　　处：《中国中西医结合杂志》2001年第8期585-587,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：河北省张家口市科委科研基金资助 (No.991 1 2 1 )

摘　　要：目的 :观察急性过敏性紫癜 (HSP)患儿免疫功能的改变 ,采用中西医结合治疗的方法 ,探讨中药银浮汤加转移因子对急性HSP患儿免疫功能的调节作用。方法 :观察组 (35例 )采用中药银浮汤加转移因子治疗 ,并与采用常规治疗的对照组 (35例 )比较。治疗前后进行IgG、IgA、IgM、CD3、CD4 、CD8、CD4 /CD8比值、红细胞C3b受体花环率及免疫复合物花环率的检测。同时与 4 0名健康儿童作健康对照 ,观察治疗前后免疫指标的变化。结果 :治疗前 (急性期 )与健康对照组比较 ,IgA、IgM、CD4 、CD4 /CD8比值 ,红细胞C3b受体花环率均明显升高 ,而CD8明显下降 ,差异均有显著性 (P <0 0 1)。观察组与对照组治疗前后免疫指标的比较差异亦有显著性 (P <0 0 1) ,而观察组更优于对照组 (P <0 0 5)。观察组愈显率与对照组比较差异亦有显著性 (P <0 0 1)。结论 :急性HSP存在多种免疫功能的改变 ,中药银浮汤加转移因子治疗 ,具有明显调节免疫功能的作用 ,是一种副作用少 ,复发率低 。Objective: To observe the changes of immune function in children with acute Henoch-Schonlein purpura (AHSP) and the effects of integrated traditional Chinese and western medicine (TCM-WM) on it. Methods: Immunological criteria in TCM-WM group (n=35) treated by Yinfu Decoction (YFD) combined with transfer factor and 35 patients in the control group (n=35) treated by conventional treatment were observed and compared before and after treatment. Also the criteria were compared with those of 40 healthy subjects. Results: Before treatment, the levels of IgA, IgM, CD 4, CD 4/CD 8 ratio, rosette forming rate of RBC-C 3b receptor in patients were higher than those in the healthy subjects, but the levels of CD 8 was obviously lower, the difference was significant (P<0.01). The above-mentioned criteria were all improved in the two treated groups after treatment, and the improvement was more significant in the TCM-WM group than that in the control group (P<0.05). Besides, the cure-markedly effective rate in the former was better than that in the latter significantly (P<0.01). Conclusion: There exist multiple immune functional disturbance in AHSP patients. Combined treatment of YFD and transfer factor has obvious immune regulatory effect and is an effective therapy with few side-effects and low recurrence rate.

关 键 词：过敏性紫癜 免疫功能 中西医结合治疗 

分 类 号：R554.6[医药卫生—血液循环系统疾病]