大剂量环磷酰胺冲击治疗系统性红斑狼疮时的闭经危险  

The Risk of Sustained Amenorrhea in Patients with Systemic Lupus Erythematosus Receiving Intermittent Pulse Cyclophosphamide Therapy

作　　者：刘钢[1] 陈永涛[1] 王玲[1] 左川[1] 谢其冰[1] 王忠明[1] 林懋贤[1] 

机构地区：[1]华西医科大学附属第一医院临床免疫科,成都610041

出　　处：《华西医科大学学报》2001年第2期294-295,306,共3页Journal of West China University of Medical Sciences

摘　　要：目的　研究大剂量环磷酰胺冲击治疗系统性红斑狼疮时的闭经危险。方法　前瞻性对比研究 5 1例接受大剂量环磷酰胺冲击治疗的生育期女性患者与 2 2例接受甲基强的松龙治疗的生育期女性患者的闭经发生率及其规律。结果　大剂量环磷酰胺冲击治疗组闭经率 19.6 % ,比甲基强的松龙治疗组的闭经率明显增高 (P=0 .0 2 5 ) ;大剂量环磷酰胺冲击治疗组中 ,年龄大于 30岁组比 30岁及 30岁以下组闭经率高 (P=0 .0 0 18)。结论　大剂量环磷酰胺冲击治疗系统性红斑狼疮时 ,生育期女性患者闭经率升高。年龄愈大 。Objective To determine the risk of sustained amenorrhea in premenopausal women with systemic lupus erythematosus (SLE) receiving intermittent pulse cyclophosphamide (CTX) therapy. Methods Prospectively comparing the amenorrhea rate of 51 cases receiving intermittent pulse cyclophosphamide therapy versus that of 22 cases receiving intermittent pulse methylprednisolone (MP) therapy. Results The amenorrhea rate was higher in the CTX group (19.6%) than in the MP group ( P =0.025).In the CTX group, the amenorrhea rate of patients aged over 30 was higher than that of patients aged 30 or below 30 ( P =0.0018). Conclusion Pulse CTX therapy in fertile women with SLE is associated with increased rate of sustained amenorrhea, and the older the patient is, the higher risk for sustained amenorrhea the patient runs.

关 键 词：系统性红斑狼疮 环磷酰胺 冲击治疗 闭经 

分 类 号：R593.241[医药卫生—内科学] R711.51[医药卫生—临床医学]