盐酸去氢骆驼蓬碱软膏的处方筛选  

Prescription Selecting of Harmine. HCl Ointment

作　　者：邢建国[1] 孙殿甲[1] 管慧 王双全 寇耀红[1] 

机构地区：[1]新疆医科大学药学院,新疆乌鲁木齐830054 [2]新疆八一钢铁(集团)公司职工医院,新疆乌鲁木齐830022

出　　处：《中成药》2001年第5期316-318,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :筛选盐酸去氢骆驼蓬碱软膏的处方组成。方法 :采用正交试验设计 ,以软膏中有效成分盐酸去氢骆驼蓬碱的透皮吸收速度常数K和流动活化能Eη 为考察指标。结果 :得到最佳基质处方为 :氮酮 (2 .0 % )、司盘 80 (0 .2 % )、吐温 80 (0 .4% )、单硬脂酸甘油酯 (2 .5 % )、凡士林 (4 .0 % )、液体石蜡 (11% )。结论 :该软膏处方设计合理、制剂稳定性好。Objective: To select the prescription of Harmine HCl ointment. Methods: The orthogonal design was used for selecting the prescription with transdermal absorption rate constant (K) and flow energy of activition (E η) as selecting standard. Results: The optimum prescription is as follows: Azone (2.0%), Span-80 ( 0.2%), Tweens-80 (0.4%), Glycerylmonostearate (2.5%), Vaselin (4.0%), Liquid (11%). Conclusion: The prescription design is available, and the ointment has a good stability.

关 键 词：盐酸去氢骆驼蓬碱 软膏 处方 正交试验 透皮吸收 流变学 

分 类 号：R944.21[医药卫生—药剂学] R965.1[医药卫生—药学]