黄芩甙-羟丙基-β-环糊精包合物的研究  

Study on the Inclusion Compound of Baicalin with Hydroxypropyl-β-Cyclodextrin

作　　者：邵伟[1] 袁敏[1] 王大庆[2] 王春香[1] 米广太[1] 

机构地区：[1]山东大学药学院,山东济南250012 [2]山东师范大学测试中心,山东济南250014

出　　处：《中成药》2001年第5期318-321,共4页Chinese Traditional Patent Medicine

摘　　要：目的 :制备黄芩甙 羟丙基 β 环糊精包合物并对其加以鉴定。 方法 :采用冷冻干燥法制备黄芩甙 羟丙基 β 环糊精包合物。结果 :经红外光谱测试、差示扫描量热分析等方法对包合物进行了鉴定 ,表明黄芩甙与羟丙基 β 环糊精已形成包合物 ,含量测定证明包合物主、客分子比为 1∶1。结论 :黄芩甙 羟丙基 β 环糊精包合物可明显提高黄芩甙的溶解度 ,黄芩甙的溶解度由原来的 0 .112mg/mL增至包合后的 2 .743mg/mL。Objective: To prepare the inclusion compund of baicalin-hydroxypropyl-β-cyclodextrin (HP-β-CD) and identify it. Methods: The inclusion compound of baicalin-HP-β-CD was confirmed by freeze-drying method. Results: The inclusion compound of baicalin-HP-β-CD was confirmed by IR absorption spectroscopy and differential scanning calorimetry (DSC). The results indicated that the inclusion compound of baicalin-HP-β-CD was formed. The content analysis of the inclusion compound showed that the molecular ratio of baicalin to HP-β-CD was 1∶1. Conclusion: The solubility of baicalin is increased from 0.112mg/ml to 2.743mg/ml. when the drug is included by HP-β-CD.

关 键 词：黄芩甙 羟丙基-Β-环糊精 包合物 冷冻干燥法 红外光谱法 差示扫描量热分析 

分 类 号：R944.9[医药卫生—药剂学]